The N-Ras gene specifies two main transcripts of 2 kb and 4.3 kb. The difference between the two transcripts is a simple extension through the termination site of the 2 kb transcript. The N-Ras gene consists of seven exons (-I, I, II, III, IV, V, VI).

Mar 30, 2025 · NRAS (NRAS Proto-Oncogene, GTPase) is a Protein Coding gene. Diseases associated with NRAS include Ras-Associated Autoimmune Leukoproliferative Disorder and Melanocytic Nevus Syndrome, Congenital. Among its related pathways are Downstream signaling of activated FGFR2 and Prolactin Signaling.

The NRAS gene provides instructions for making a protein called N-Ras that is involved primarily in regulating cell division. Through a process known as signal transduction, the protein relays signals from outside the cell to the cell's nucleus.

RAS proteins are small GTPases that are central mediators downstream of growth factor receptor signaling and therefore critical for cell proliferation, survival, and differentiation. NRAS is implicated in the pathogenesis of several cancers (for review see PMID: 17384584).

May 16, 2020 · Gene target information for NRAS - NRAS proto-oncogene, GTPase (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.

Gene ID: 4893, updated on 8-Feb-2025. This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex.

The NRAS gene mutations found in colorectal (bowel) cancer are somatic, which means they occur in non-reproductive cells and are not hereditary. NRAS is both a prognostic and predictive biomarker.

NRAS (neuroblastoma ras viral oncogene homolog) is a member of the Ras superfamily of low-molecular-weight plasma-membrane associated GTP-binding proteins. Ras proteins primarily regulate cell growth, differentiation and survival.

NRAS, NRAS proto-oncogene, GTPase, is a member of the family of small GTPase that when activated by growth factors, stimulates multiple effector pathways such as RAF and PI3K to …

Apr 1, 2025 · What is an NRAS biomarker? NRAS is a member of the RAS family of genes that include KRAS and HRAS. A normal NRAS gene teams up with a group of proteins as an “on/off” switch to monitor cell growth. An abnormal mutation in the NRAS gene happens early in the development of cancer.