Neurokinin B (NKB) belongs in the family of tachykinin peptides. Neurokinin B is implicated in a variety of human functions and pathways such as the secretion of gonadotropin-releasing hormone. [1] Additionally, NKB is associated with pregnancy in females and maturation in …

Neurokinin B (NKB) and its cognate receptor (NK3R) are emerging as important components of the neuroendocrine regulation of reproduction. Unlike mammalian tac3, which encodes only one mature peptide (namely NKB), two mature peptides are predicted ...

Neurokinin B (NKB) is a member of the tachykinin family of peptides. Inactivating mutations in the tachykinin 3 or tachykinin 3 receptor gene are associated with pubertal failure and congenital hypogonadotrophic hypogonadism in humans. This suggests that NKB may have a critical role in human reproduction.

Neurokinin B, encoded by the TAC3 gene (GenBank accession no. NM_0013251), is a member of mammalian tachykinins family of excitatory neurotransmitters, composed of evolutionary and conserved peptides widely distributed within the peripheral and central nervous system (Pinto et …

Loss of function mutations in the genes encoding either neurokinin B (NKB) or its receptor, NK3 (NK3R), result in hypogonadotropic hypogonadism, characterized by an absence of pubertal development and low circulating levels of LH and gonadal steroids. These studies implicate NKB and NK3R as essential elements of the human reproductive axis.

Jan 14, 2010 · We hypothesized that elevated levels of neurokinin B may be an indicator of pre-eclampsia and that treatment with certain neurokinin receptor antagonists may be useful in alleviating the symptoms. At the time of the original hypothesis many …

Jan 1, 2021 · Neurokinin B (NKB) is a member of the vertebrate tachykinins (TKs) and conserves the C-terminal tachykinin motif, Phe-Xaa-Gly-Leu-Met-amide. NKB is encoded by tac3, which is paralogous to tac1. Tetrapod tac3 encodes only a single NKB sequence, whereas teleost tac3 also encodes another TK, neurokinin F (NKF), as well as NKB.

Jul 16, 2014 · NKB is a neurotransmitter with various roles, such as vascular reactivity, smooth muscle contraction, and vascular inflammation. A previous study has claimed that substance P which, like NKB, is from the tachykinin family and increases mast cell-dependent atherosclerotic plaque destabilization.

The fastest train from Nagrakata to Siliguri Jn is the Sikkim Mahananda Express which covers a distance of 70 kilometres in approximately 2 Hours 13 Minutes. RailYatri provides train travellers an easy online train ticket booking platform with a large number of IRCTC trains to choose from across the country.

Neurokinin B (NKB) is an endogenous peptide that belongs to the family of tachykinins. For many years, it was considered that its expression was restricted to the central nervous system and the spinal cord.