The dTAG system for immediate and target-specific protein ... - PubMed
Using dTAG, we observe an unexpected superior antiproliferative effect of pan-BET bromodomain degradation over selective BRD4 degradation, characterize immediate effects of KRAS G12V …
Rapid and direct control of target protein levels with VHL
Sep 18, 2020 · We describe dTAG V -1, an exclusively selective VHL-recruiting dTAG molecule, to rapidly degrade FKBP12 F36V -tagged proteins. dTAG V -1 overcomes a limitation of …
Immune heterogeneity in small-cell lung cancer and vulnerability …
Nabet et al. utilize RNA-seq from a large randomized SCLC clinical trial to identify four patient subsets with distinct neuroendocrine (NE) phenotypes, immune composition, and benefit from …
Noninvasive Early Identification of Therapeutic Benefit from …
Oct 15, 2020 · Here, we demonstrate that pre-treatment circulating tumor DNA (ctDNA) and peripheral CD8 T cell levels are independently associated with DCB. We further show that …
Targeted Protein Degradation Tools: Overview and Future …
In this review, we focus on anchor-away, deGradFP, auxin-inducible degron (AID) and dTAG technologies and discuss their recent applications and advances. Finally, we propose nano …
Nabet Lab - Fred Hutch
The Nabet lab is dedicated to targeting oncogenic signaling networks through control of protein homeostasis to advance new therapeutic strategies in cancer.
Blood-Based Biomarkers for Predicting Immunotherapy Benefit in Lung ...
Oct 15, 2020 · In this issue of Cell, Nabet et al. report a novel, blood-based methodology to more accurately predict durable disease control with immunotherapy. Two largely separate …
TAGing for destruction - Nature Chemical Biology
Mar 26, 2018 · A new study by Nabet et al. 1 showed that proteins fused with FKBP12 F36V, a mutant of the 12-kDa FK506-binding protein (FKBP12), can be rapidly degraded in cultured …
The dTAG system for immediate and target-specific protein
Mar 26, 2018 · Using dTAG, we observe an unexpected superior antiproliferative effect of pan-BET bromodomain degradation over selective BRD4 degradation, characterize immediate …
Rapid and direct control of target protein levels with VHL ... - Nature
Sep 18, 2020 · Nabet, B., Ferguson, F.M., Seong, B.K.A. et al. Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules. Nat Commun 11 , 4687 (2020)....