Dec 6, 2022 · In this Article, we engineered mesenchymal stem cells (MSCs) with tumour-targeted adjustable delivery of SIL2, a super IL-2 mutein dimer, to preferentially activate CD8 + TILs.

NQO1 removes quinone from biological systems through detoxification reaction: NAD(P)H + a quinone → NAD(P) + + a hydroquinone. This reaction oxidises the substrate without the formation of damaging semiquinone and oxygen free radical species.

Here, we report a novel function of NQO1 in modulation of the cell cycle regulator, cyclin-dependent kinase subunit-1 (CKS1), at the G2/M phase through effects on the stability of c‑Fos.

Jul 19, 2019 · Our study reveals that targeting NQO1 potently triggers innate sensing within TME that synergizes with immunotherapy to overcome adaptive resistance.

Jun 1, 2019 · In order to design fluorescence probe for NQO1 detection and bioimaging, a NQO1 responsive probe was synthesized, which comprised of a fluorescence reporting unit (NBD fluorophore) and a NQO1 responsive unit (quinone acid).

Jun 17, 2022 · NQO1 levels were not altered by MSC treatment (Fig. 2I, J). Nrf2-dependent heme oxygenase 1 (HO-1) was increased in untreated patient fibroblasts compared to healthy controls; however, differences were not statistically significant (Fig. 2 I, K).

In this article we will focus on NQO1, its functions, polymorphisms and potential relevance to ubiquinone mediated antioxidant protection. In addition, we will summarize data which points to a potential role for the redox environment in controlling NQO1 structure and downstream functions.

Established roles for NQO1 include a superoxide reductase activity, NAD + generation, interaction with proteins and their stabilization against proteasomal degradation, binding and regulation of mRNA translation and binding to microtubules including the mitotic spindles.

Jan 3, 2020 · We found NQO1 low cells form aggressive tumors compared with NQO1 high cells. Biopsy specimens and circulating tumor cells showed biochemical recurrent prostate cancer was associated with low...

Jul 5, 2016 · Immunohistochemical staining and Western blot assays were used to assess the expression levels of NQO1 in HNC cells and tumors. Forty-five percent of endogenous HNCs expressed elevated NQO1 levels.