NPM1 is a transcriptional target of MYC [39,40]. MYC overexpression increases protein synthesis; therefore, NPM1 is a key transcriptional target, given its numerous functions. NPM1 controls Myc-induced proliferation and transformation by binding directly to Myc and regulating its binding to promotors of target genes [30,41]. 2.3. NPM1 Gene ...

Oct 24, 2023 · Mechanistically, NPM1 influences and cooperates with BRD4 to facilitate c-Myc transcription to promote PCa progression. In addition, JQ1, a bromodomain and extra-terminal domain (BET) inhibitor,...

Jan 30, 2025 · A 49-year-old woman with history of acute myeloid leukemia (AML) with NPM1 mutation after multiple rounds of chemotherapy was evaluated for minimal residual disease (MRD). The bone marrow aspirate smear revealed rare blasts (panel A; hematoxylin and eosin stain [H&E], 100× lens objective, original magnification ×1000), and the biopsy showed ...

Even though amplification of the NPM1 locus has never been shown, the NPM1 gene is a target of the oncogenic c-MYC, which stimulates NPM1 expression by direct binding to the NPM1 promoter . The specific contribution of overexpressed NPM1 to cancer development is not fully understood but it may arise from multiple factors.

Somatic mutations in exon 12 of the NPM gene (NPM1) are the most frequent genetic abnormality in adult AML, found in approximately 35% of all cases and up to 60% of patients with normal karyotype AML. In children, NPM1 mutations are far less frequent, occurring in 8–10% of all AML cases, and in approximately 25% of those with a normal karyotype.

Jan 10, 2025 · Our results revealed an upregulated ribosome (RB) signature in the MYC -amplified G3 subtype and identified NPM1, which exhibited the highest risk of poor prognosis, as a potential druggable...

Oct 24, 2023 · Mechanistically, NPM1 influences and cooperates with BRD4 to facilitate c-Myc transcription to promote PCa progression. In addition, JQ1, a bromodomain and extra-terminal domain (BET) inhibitor, in combination with NPM1 inhibition suppresses PCa …

Aug 3, 2012 · Here we present the solution structure of the NPM1-C70 domain and NMR analysis of its interaction with a c-MYC-derived G-quadruplex. These data were used to calculate an experimentally restrained molecular docking model for the complex.

MYC regulates the transcription of thousands of genes required to coordinate a range of cellular processes, including those essential for proliferation, growth, differentiation, apoptosis and...

Jan 10, 2025 · Inhibition of NPM1 led to apoptosis, reduced c-Myc stability, and impaired translation in MYC-amplified Group 3 MB cells. Together, our findings highlight NPM1 as a promising therapeutic target and provide new insights into the regulatory mechanisms in MB.