Sep 6, 2022 · We report here the reaction of α-fluoronitroalkanes and N-aryl hydroxyl amines for the direct synthesis of N-aryl amides using a simple Brønsted base as the promoter.

Nov 8, 2024 · We report the discovery of a boron-driven ortho-arylation reaction of N-aryl amides and ureas. This novel method enables directed borylation of a wide range of substrates, leading to the synthesis of unique compounds such as N -doped fulminene and diagonal tetraarylbenzenediamines.

Dec 17, 2024 · We present a highly selective protocol for the ortho benzylation of N-aryl amides. This method offers mild conditions, excellent site specificity, and scalability, enabling the synthesis of diarylmethane amides and dibenzoazepines.

Sep 26, 2022 · This paper describes a mild strategy to promote amide arylations. Photoinduced oxidation of a Ni(II) aryl amido intermediate is proposed to facilitate the challenging C–N reductive elimination step at moderate temperatures.

We report the efficient N-arylation of acyclic secondary amides and related nucleophiles with aryl nonaflates, triflates, and chlorides. This method allows for easy variation of the aromatic component in tertiary aryl amides.

Aug 13, 2022 · We found that the N-allylation reaction of a broad range of N-aryl substituted amides 1 bearing different substituents with MBH carbonate 2a proceeded smoothly under the optimized conditions, providing the corresponding products in moderate to good yields. All the reactions completed within 1 h.

Jul 28, 2020 · Two robust and efficient mechanochemical protocols for the synthesis of an array of N -arylamides have been developed. This was achieved by a C−N cross-coupling between O -pivaloyl hydroxamic acids and aryl iodides or aryl boronic acids, in the presence of a stoichiometric amount of a copper mediator.

The N-aryl amide analogs of piperine 3–5 were designed by the replacement of the piperidine moiety with aryl amine-containing phenyl, 2,4-dimethoxyphenyl, and 2,5-dimethoxyphenyl substituents to improve its drug-likeness properties.

May 9, 2017 · Catalytic ring-opening of bio-sourced non-strained lactones with aromatic amines can offer a straightforward, 100 % atom-economical, and sustainable pathway towards relevant N-aryl amide scaffolds.

We report here the reaction of α-fluoronitroalkanes and N -aryl hydroxyl amines for the direct synthesis of N -aryl amides using a simple Brønsted base as the promoter.