Oct 11, 2016 · Myelin is essential to the conduction of nerve impulses in the brain and spinal cord, and myelin loss is a key pathophysiological component of neurological injury and disease, including multiple sclerosis, traumatic brain and spinal cord injury, stroke, and some neuropsychiatric disorders.

Apr 27, 2024 · In this disease, the immune system attacks the myelin sheath or the cells that produce and maintain it. The attack causes swelling, also known as inflammation, and injury to the myelin sheath. Ultimately, the nerve fibers the myelin sheath surrounds are damaged. The process can result in areas of scarring, known as sclerosis. Other causes

Jan 3, 2024 · Myelin oligodendrocyte glycoprotein antibody-associated disease, also known as MOGAD, is a rare inflammatory disease that affects the central nervous system. In MOGAD , the immune system attacks the fatty substance that protects nerve fibers in the optic nerves, brain and spinal cord.

Jan 3, 2024 · Sechi E, et al. Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD): A review of clinical and MRI features, diagnosis, and management. The Frontiers in Neurology. 2022; doi:10.3389/fneur. 2022.885218 .

Jan 3, 2024 · Called MOGAD, which stands for myelin oligodendrocyte glycoprotein associated-antibody disease, the rare, immune-mediated illness has been present in Joe’s life since February 2016, when, at the age of 55,…

Mar 22, 2025 · The MOGAD Clinic helps people with a rare, newly defined condition called myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD). It's an autoimmune disorder in which the body's immune system attacks the outer covering of its nerves, called myelin. This leads to inflammation of the brain, optic nerve or spinal cord.

Nov 1, 2024 · In multiple sclerosis, the protective coating on nerve fibers, known as myelin, in the central nervous system is damaged. Depending on the location of the damage in the central nervous system, symptoms may happen, including numbness, tingling, weakness, visual changes, bladder and bowel troubles, memory troubles, or mood changes, for example.

May 22, 2018 · Mayo Clinic has developed the first test available in the US to identify the myelin oligodendrocyte glycoprotein (MOG) antibody in patients' blood. How does this test help with the diagnosis of inflammatory demyelinating diseases? The MOG antibody can distinguish a spectrum of autoimmune demyelinating diseases from multiple sclerosis (MS).

Feb 7, 2020 · Adrenoleukodystrophy (uh-dree-noh-loo-koh-DIS-truh-fee) is a type of hereditary (genetic) condition that damages the membrane (myelin sheath) that insulates nerve cells in your brain. In adrenoleukodystrophy (ALD), your body can't break down very long-chain fatty acids (VLCFAs), causing saturated VLCFA s to build up in your brain, nervous ...

Sep 21, 2021 · As described in a study to be published in Neurology, the findings can potentially inform the diagnosis and treatment of multiple sclerosis (MS), myelin-oligodendrocyte-glycoprotein-IgG-associated disorder (MOGAD) and aquaporin-4-IgG-positive neuromyelitis optica spectrum disorder (AQP4-IgG-NMOSD).