Recent advances suggest the medial prefrontal cortex plays an important regulatory role in numerous cognitive functions, including attention, inhibitory control, habit formation and working, spatial or long-term memory.

In the current review, we discuss the potential role of the medial prefrontal cortex (mPFC) as a coordinator of behavioral and physiological stress responses across multiple temporal and contextual domains.

Mar 8, 2019 · The medial prefrontal cortex (mPFC) is a central component of the affective cortico-limbic-striatal system that is thought to regulate behavior motivated by both reward and aversive...

May 6, 2020 · Our findings thus reveal a target cell-based dysregulation of mPFC-to-amygdala transmission for stress-induced anxiety. In the brain, the medial prefrontal cortex (mPFC) and amygdala are...

The medial prefrontal cortex (mPFC) is a crucial cortical region that integrates information from numerous cortical and subcortical areas and converges updated information to output structures. It plays essential roles in the cognitive process, ...

Feb 21, 2020 · The mPFC plays a critical role in behavior, as a central hub that receives input from cortical, thalamic, and limbic regions and sends outputs to structures that regulate emotion, fear, and...

The mPFC-RE-HC system: Understanding higher order cortico-thalamo-cortical interactions in memory. RE is a midline thalamic nucleus that projects to both the agranular mPFC, medial septum, and the stratum lacunosum molecular (slm) layers of CA1 and molecular layers of subiculum throughout the HC.

Aug 15, 2015 · The medial prefrontal cortex (mPFC) plays a critical role in multiple cognitive and limbic functions. Given its vital importance, investigating the function of individual mPFC circuits in animal models has provided critical insight into the neural basis underlying different behaviors and …

The mPFC elicits top-down control over subcortical regions such as the basal ganglia and limbic structures that affect memory, motivation, and emotional behaviors (Miller & Cohen, 2001). Consequently, mPFC dysfunction alters behavioral output.

Feb 4, 2020 · The medial prefrontal cortex (mPFC) is a critical component of a cortico-basal ganglia-thalamo-cortical loop regulating limbic and cognitive functions. Within this circuit, two distinct nucleus accumbens (NAc) output neuron types, dopamine D1 or D2 receptor-expressing neurons, dynamically control th …