Here, we review this rich body of literature, aligning major events in mPFC development with the maturation of complex behaviors. We focus on emotional memory and cognitive flexibility, and highlight new work linking mPFC circuit disruption to alterations of …

Nov 9, 2023 · Using calcium imaging and optogenetic manipulation during memory-guided behavior, we show that working-memory coding and the relevant recurrent connectivity in the mouse medial prefrontal...

May 18, 2023 · Our findings indicate that chronic stress exposure preferentially modulates the activity of the mPFC-BLA circuit in a subregion (dmPFC) and laminar (layer V) -dependent manner. Chronic stress exposure increases the risk of mental health problems such as anxiety and depression.

we describe the cellular diversity of the rodent mPFC, the impact of long-range afferents, and the specificity of local microcircuits. We highlight similarities with and differences between other cortical areas, illustrating how the circuit organization of the …

Here we review recent progress in understanding the circuit organization of the mPFC in rodents, focusing on emerging rules of cell- and synapse-specific connectivity.

Mar 31, 2021 · Collectively, we show that mPFC output pathways targeting anatomically and functionally distinct striatal and thalamic subregions encode bi-directional command of cognitive control. Cognitive...

Jan 1, 2016 · We sought to test the hypothesis that elevated medial prefrontal cortex (mPFC) excitability (a clinical feature associated with anhedonia) exerts suppressive control over the interactions between two distant subcortical regions: the dopaminergic midbrain and the striatum.

The rodent medial PFC (mPFC) possesses an enormous variety of projection neurons and interneurons. These cells are engaged by long-range inputs from other brain regions involved in cognition, motivation, and emotion.

Feb 21, 2020 · Recently developed optogenetic and chemogenetic tools that allow high-fidelity control of neuronal activity in preclinical models have begun to elucidate the contributions of the PFC and its...

Aug 29, 2019 · In the present review, we summarize the preclinical and clinical studies to illustrate the role of the mPFC in these neurological diseases. The medial prefrontal cortex (mPFC) is a cortical region with different cell types and projections.