MIA PaCa-2 is an epithelial cell line that was derived from tumor tissue of the pancreas obtained from a 65-year-old, White male. This cell line can be used in cancer research. Please fill out the form below to sign up for notification when the product becomes in stock. You were successfully signed up for notification.

Feb 17, 2016 · Thus, the aim of this study was to describe those MIA PaCa-2 and PANC-1 cell line phenotype and genotype characteristics that may play a crucial role in pancreatic cancer therapeutic assays,...

MIA PaCa-2 is a human pancreatic cancer cell line used extensively in pancreatic cancer research and therapy development. [1] In 1977, [2] MIA PaCa-2 cells were derived from the carcinoma of a 65-year-old male. [citation needed]

Feb 5, 2025 · Derived from a human pancreatic carcinoma, MIA PaCa-2 cells are widely used in cancer research. Known for their epithelial-like morphology, characterized by a cobblestone …

Human pancreatic carcinoma (MIA PaCa-2) in continuous culture: sensitivity to asparaginase. Abnormalities of the p53 tumour suppressor gene in human pancreatic cancer. Human pancreatic carcinomas and cell lines reveal frequent and multiple alterations in the p53 and Rb-1 tumor-suppressor genes.

To investigate mechanisms of gemcitabine resistance, the MiaPaCa-2 (MP) cell line was selected for survival under continuous exposure to gemcitabine. Selection was initiated at 20 nM gemcitabine, which corresponds to the approximate IC 50 as determined by 72 hr …

To further elucidate the roles of GSK-3β in drug-resistance, we transfected KRas-dependent MIA-PaCa-2 pancreatic cells with wild-type (WT) and kinase-dead (KD) forms of GSK-3β. Transfection of MIA-PaCa-2 cells with WT-GSK-3β increased their resistance to various chemotherapeutic drugs and certain small molecule inhibitors.

Feb 17, 2016 · Thus, the aim of this study was to describe those MIA PaCa-2 and PANC-1 cell line phenotype and genotype characteristics that may play a crucial role in pancreatic cancer therapeutic assays, namely neuroendocrine chemotherapy and …

MiaPaCa-2 xenograft is a preclinical model of pancreatic cancer that involves the transplantation of MiaPaCa-2 cells into immunocompromised mice. This model is widely used in pancreatic cancer research to study the in vivo behavior of MiaPaCa-2 cells and to test the efficacy of potential therapeutic agents.

Feb 19, 2020 · MIA PaCa-2, an established human pancreatic ductal adenocarcinoma (PDAC) cell line, contains round and spindle-shaped adherent cells, as well as, round floating cells. In this study, we aimed to assess if the floating cells might have greater metastatic potential and/or be more resistant to drug-induced apoptosis compared to adherent cells.