Eukaryotic MCM consists of six gene products, Mcm2–7, which form a heterohexamer. [ 1 ] [ 2 ] As a critical protein for cell division, MCM is also the target of various checkpoint pathways, such as the S-phase entry and S-phase arrest checkpoints.

Summary: The Mcm2-7 complex serves as the eukaryotic replicative helicase, the molecular motor that both unwinds duplex DNA and powers fork progression during DNA replication. Consistent with its central role in this process, much prior work has ...

Jul 24, 2018 · A heterohexameric complex composed of minichromosome maintenance protein 2–7 (MCM2–7), which acts as a key replicative enzyme in eukaryotes, is crucial for initiating DNA synthesis only once per cell cycle.

Jun 25, 2021 · Inhibition of MCM2-7 by treatment with ciprofloxacin inhibits NEPC cell proliferation and migration in vitro, significantly delays NEPC tumor xenograft growth, and partially reverses the...

Here, we summarize what is known about the non-replication roles of MCM helicase, best known for its ability to unwind double-stranded DNA templates during DNA replication. The MCM2-7 complex is a hexameric protein complex that serves as a DNA helicase.

MCM2-7, evolutionarily conserved and essential for DNA replication, functions as the central factor for the eukaryotic replicative DNA helicase. Here, we summarize the roles of MCM2-7 in the initiation and progression of replication forks, with a ...

Oct 14, 2022 · Nature Communications - For several decades the MCM2-7 proteins, the core of the DNA replicative helicase, eluded detection at DNA replication sites. Here, the authors solve this conundrum by...

Aug 24, 2024 · Mapping the molecular footprints of budding yeast ORC and MCM2-7 genome-wide, we discovered that MCM2-7 loading is associated with ORC release from origins and redistribution to non-origin...

Apr 13, 2024 · Here, we summarize what is known about the non-replication roles of MCM helicase, best known for its ability to unwind double-stranded DNA templates during DNA replication. The MCM2-7 complex is a hexameric protein complex that serves as a DNA helicase.

DNA replication licensing factor MCM7 is a protein that in humans is encoded by the MCM7 gene. [5] The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication.