Mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4) – also known as hepatocyte progenitor kinase-like/germinal center kinase-like kinase (HGK) and Nck-interacting kinase …

Oct 28, 2016 · MAP4K4, also known as HGK (hematopoietic progenitor kinase/germinal center kinase-like kinase) or NIK (Nck interacting kinase, the mouse ortholog) is a serine/threonine …

Mar 30, 2025 · MAP4K4 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4) is a Protein Coding gene. Diseases associated with MAP4K4 include Anus, Imperforate and Renal …

This study has identified serine/threonine kinase mitogen-activated protein 4 kinase 4 (MAP4K4) as a novel positive regulator of MAPK/ERK signaling in lung adenocarcinoma. The results …

Map4k4, originally identified in siRNA screens and characterized by tissue specific gene deletions, is emerging as a regulator of glucose homeostasis and cardiovascular health.

MAP4K4 has been investigated for its regulatory role in metabolic and inflammatory diseases and various cancers. Recent understanding of MAP4K4 in malignant diseases suggests a critical …

Syndromic craniosynostosis caused by a novel missense variant in MAP4K4: Expanding the genotype-phenotype relationship in RASopathies. MAP4K4 exacerbates cardiac …

Jan 11, 2023 · Screening with GeRPs for inflammation genes revealed that Map4k4 is a mediator of cytokine expression. Importantly, silencing Map4k4 in macrophages in vivo protected mice …

Dec 21, 2015 · Here we demonstrate that the Sterile-20-like mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4), which has been implicated in inflammation, is abundantly …

Oct 28, 2016 · MAP4K4, also known as HGK (hematopoietic progenitor kinase/germinal center kinase-like kinase) or NIK (Nck interacting kinase, the mouse ortholog) is a serine/threonine …