Jul 1, 2012 · MYC-associated protein X (MAX) is a ubiquitous, constitutively expressed protein that plays a central role in controlling the MYC/MAX/MAX dimerization protein 1 (MXD1) axis, one of the better-known cellular networks whose deregulation contributes to the genesis of many human cancers.

MAX (also known as myc-associated factor X) is a gene that in humans encodes the MAX transcription factor. [5][6] The protein product of MAX contains the basic helix-loop-helix and leucine zipper motifs. It is therefore included in the bHLHZ family of transcription factors.

We present a view of MYC as a sensor that integrates multiple cellular signals to mediate a broad transcriptional response controlling many aspects of cell behavior. We also describe the larger transcriptional network linked to MYC with emphasis on the MXD family of MYC antagonists.

Jul 3, 2018 · MYCMI-6 exhibits strong selective inhibition of MYC:MAX interaction in cells and in vitro at single-digit micromolar concentrations, as validated by split Gaussia luciferase, in situ proximity...

Direct strategies to inhibit MYC (blue box) include approaches using small molecules, peptides or ‘miniproteins’ to inhibit MYC–MAX dimerization, sequester MAX via homodimer stabilization, or interfering with MYC–MAX binding to target DNA sequences.

Jun 29, 2021 · MYC–MAX interaction enables binding to DNA through the BRs on both proteins and is therefore important to overall MYC function 23,24. Other MYC interactors have since been identified and...

Although MAX is regarded as an obligate dimerization partner for MYC, its function in normal development and neoplasia is poorly defined. We show that B-cell-specific deletion of Max has a modest effect on B-cell development but completely abrogates Eµ- Myc- driven lymphomagenesis.

Using a novel combination of chemical and photo-cross-linking analysis, we demonstrate that either Max or a c-Myc/Max heteromeric complex binds to DNA virtually exclusively in a dimeric structure. Using fusion proteins in cultured cells, we establish a number of functional characteristics of Max.

Sep 25, 2023 · In this study, we found that developmental arrest occurs at the two-cell stage when mouse embryos were treated with antisense oligonucleotides targeting Myc or MYC-specific inhibitors from...

Jan 24, 2003 · In this paper, we report cocrystal structures of chemoselectively ligated c-Myc-Max (hereafter Myc-Max) and Mad1-Max (hereafter Mad-Max) heterodimers bound to duplex oligonucleotides containing E boxes.