In pyrimidine synthesis, MYC is known to regulate carbamoyl-phosphate synthetase (CAD), one of the earliest identified MYC target genes .

CADとCAMのバランスのいいシステムを目指し開発しています。 2019年4月1日 事務所移転しました。 (新しい連絡先 Tel 0561-61-3210 Fax 0561-61-3212）

Dec 21, 2001 · In summary, our results suggest that c-Myc activates transcription of cad by stimulating promoter clearance and elongation, perhaps via recruitment of P-TEFb. c-Myc is a …

Using a chromatin immunoprecipitation assay, we found high levels of RNA polymerase II bound to the cad promoter in quiescent NIH 3T3 cells and in differentiated U937 cells, even though …

Several promoters have been proposed to be c-Myc targets based on this criterion; dihydrofolate reductase (DHFR) and carbamoyl-phosphate synthase (CAD) both contain E2F as well as the …

However, it was unknown whether upregulation of CAD, which performs the first three rate-limiting steps of pyrimidine biosynthesis, contributes to c-Myc's role in human neoplasia. To explore …

Apr 18, 2013 · The association of CAD and mLST8 was further examined by overexpressing both proteins with different epitope tags in HEK293 cells: analysis showed that FLAG-mLST8 and …

We report here that the expression of virtually all proposed c-Myc target genes is unchanged in cells containing a homozygous null deletion of c-myc. Two noteworthy exceptions are the gene …

Dec 21, 2001 · In summary, our results suggest that c-Myc activates transcription of cad by stimulating promoter clearance and elongation, perhaps via recruitment of P-TEFb. The c-Myc …

Oct 18, 2002 · The c-Myc protein is up-regulated in many different types of cancer, suggesting that a detailed understanding of Myc function is an important goal. Our previous studies have …