During embryonic development, MMP-13 is expressed in the skeleton as required for restructuring the collagen matrix for bone mineralization. In pathological situations it is highly overexpressed; this occurs in human carcinomas, rheumatoid arthritis and osteoarthritis.

Matrix metalloproteinase-13 (MMP-13) is the primary MMP involved in cartilage degradation through its particular ability to cleave type II collagen. Hence, it is an attractive target for the treatment of OA.

Her research showed that degeneration is caused by perturbations in the epidermis due to an increase in matrix-metalloproteinase 13 (MMP-13), an enzyme that degrades the collagen, or “glue,” between the cells.

Feb 10, 2025 · Matrix metalloproteinase 13 (MMP13) plays a crucial role in neuropathy, impacting both tissue remodeling and neuroinflammation. Understanding MMP13’s involvement is vital as it contributes to the progression of various neurological disorders by …

Matrix metalloproteinase-13 (MMP-13), an important member of matrix metalloproteinases (MMPs) family, plays a vital role by degrading type II collagen in articular cartilage and bone in OA. It is noted that MMP-13 is specially expressed in the OA patients, and not in normal adults.

Matrix metalloproteinase-13 (MMP-13) was identified as a common up-regulated gene by cancer invasion-related factors. Although MMP-13 slightly promoted tumor invasion, we found that MMP-13 was involved in tumor angiogenesis.

MMP-13 is a very important metalloproteinase during skeletal growth and long bone maturation, as the MMP-13-mediated degradation of pre-existing extracellular matrix proteins has proved to be a necessary and important step in bone development prior to …

Mar 30, 2025 · MMP13 (Matrix Metallopeptidase 13) is a Protein Coding gene. Diseases associated with MMP13 include Spondyloepimetaphyseal Dysplasia, Missouri Type and Metaphyseal Dysplasia, Spahr Type. Among its related pathways are Gene expression (Transcription) and Collagen chain trimerization.

Jan 8, 2013 · The purpose of this study was two-fold: 1) to investigate the role of MMP13 in the development of OA; and 2) to evaluate the efficacy of the MMP13 inhibitor CL82198 as a pharmacologic treatment for preventing OA progression.

Nov 10, 2017 · In this review, we highlight the main MMP-13-related changes in OA chondrocytes, including alterations in the activity and expression level of MMP-13 by upstream regulatory factors, DNA methylation, various non-coding RNAs (ncRNAs), and autophagy.