Matrix metallopeptidase 12 - Wikipedia
Matrix metalloproteinase-12 (MMP-12) also known as macrophage metalloelastase (MME) or macrophage elastase (ME) is an enzyme that in humans is encoded by the MMP12 gene. [5] …
An overview of matrix metalloproteinase-12 in multiple disease ...
Feb 5, 2025 · This review mainly focuses on the various roles of MMP-12 in different diseases along with the structural comparison with other MMPs as well as promising and MMP-12 …
Macrophage elastase (MMP-12): a pro-inflammatory mediator?
As many metalloproteinases (MMPs), macrophage elastase (MMP-12) is able to degrade extracellular matrix components such as elastin and is involved in tissue remodeling processes.
Therapeutic targeting of MMP-12 for the treatment of chronic ...
Recent studies with genetically engineered mice reported that during pulmonary inflammation, basophil-derived interleukin-4 can act on lung-infiltrating monocytes causing aberrant …
Matrix Metalloproteinase MMP-12 Promotes Macrophage …
Matrix metalloproteinases [MMPs] play an important role in extracellular matrix regulation during cell growth and wound healing. Increased expression of MMP-12 [human macrophage …
MMP-12, a Promising Therapeutic Target for Neurological Diseases
In this review, we discuss in detail the pathological role of MMP-12 and the possible underlying molecular mechanisms that contribute to disease pathogenesis in the context of central …
Optical imaging of MMP-12 active form in inflammation and …
Dec 5, 2016 · Matrix metalloproteinase (MMP)-12 plays a key role in the development of aneurysm. Like other members of MMP family, MMP-12 is produced as a proenzyme, mainly …
MMP12 Gene - GeneCards | MMP12 Protein | MMP12 Antibody
Mar 30, 2025 · MMP12 (Matrix Metallopeptidase 12) is a Protein Coding gene. Diseases associated with MMP12 include Pulmonary Emphysema and Abdominal Aortic Aneurysm. …
4321 - Gene ResultMMP12 matrix metallopeptidase 12 [ (human)]
Protective role for stromal MMP-12 in lung tumor growth; the use of the human/mouse protein chips allows us to distinguish tumor and host-derived proteases; MMP-12 is an important …
An overview of matrix metalloproteinase-12 in multiple disease ...
Feb 5, 2025 · Matrix metalloproteases (MMPs) are the proteolytic enzymes accountable for extracellular matrix (ECM) modification through their Zn 2+ -dependent catalytic activity. …
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