Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such …

Mar 30, 2025 · Complete information for MMP10 gene (Protein Coding), Matrix Metallopeptidase 10, including: function, proteins, disorders, pathways, orthologs, and expression.

Matrix metalloproteinase 10 (MMP-10, stromelysin-2) is a secreted metalloproteinase with functions in skeletal development, wound healing, and vascular remodeling; its overexpression is also implicated in lung tumorigenesis and tumor progression.

Sep 29, 2015 · Only serum MMP-10 predicted clinical deterioration within 6 months and overall survival. In IPF lungs, the expression of MMP-10 was enhanced and localized to the alveolar epithelial cells, macrophages, and peripheral bronchiolar epithelial cells. MMP-10 may be a novel biomarker reflecting both disease severity and prognosis in patients with IPF.

We report the generation of a highly selective and tightly binding MMP10 inhibitor (Ki < 2 n m). Using bio-layer interferometry–based binding assays, we found that this antibody interacts with the MMP10 active site. Activity assays demonstrated that the antibody selectively inhibits MMP10 over its closest relative, MMP3.

MMP-10, which is overexpressed in aortic valve from patients with calcific aortic stenosis, seems to play a central role in calcification in AS through Akt phosphorylation. Our results suggest that MMP-10 facilitates H. pylori persistence and promotes gastritis.

Matrix metalloproteinase-10 (MMP-10) is a zinc-dependent endopeptidase with the ability to degrade a broad spectrum of extracellular matrices and other protein substrates. The expression of MMP-10 is induced in acute kidney injury (AKI) and chronic ...

Oct 1, 2021 · MMP-10 impairs podocyte integrity by proteolytically degrading zonula occludens-1 in glomerular podocytes in vitro, ex vivo, and in vivo, leading to proteinuria. These findings highlight the potential of MMP-10 as a therapeutic target in the treatment of glomerular diseases.

Jan 12, 2021 · Matrix metalloproteinase-10 (MMP-10) is a zinc-dependent endopeptidase involved in regulating a wide range of biologic processes, such as apoptosis, cell proliferation, and tissue remodeling....

May 3, 2014 · MMP-10, one of the lesser studied MMPs, is limited to epithelial cells and can facilitate tumor cell invasion by targeting collagen, elastin and laminin. Enhanced MMP-10 expression has been linked to poor clinical prognosis in some cancers, however, mechanisms underlying a role for MMP-10 in tumorigenesis and progression remain largely unknown.