Matrix Gla protein (MGP) is member of a family of vitamin K 2 dependent, Gla-containing proteins. MGP has a high affinity binding to calcium ions , similar to other Gla-containing proteins. The protein acts as an inhibitor of vascular mineralization and plays a role in bone organization.

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Dec 25, 2024 · MGP (Matrix Gla Protein) is a Protein Coding gene. Diseases associated with MGP include Keutel Syndrome and X-Linked Chondrodysplasia Punctata 1. Among its related pathways are Endochondral ossification with skeletal dysplasias and Vitamin K metabolism and activation of dependent proteins.

Nov 23, 2021 · We examined the association of ucMGP levels with vascular calcification, arterial stiffness including carotid-femoral pulse wave velocity (PWV), and incident heart failure in community-dwelling adults from the Framingham Heart Study.

Matrix Gla protein (MGP) is a vitamin K-dependent γ-carboxylated protein that was initially identified as a physiological inhibitor of ectopic calcification, primarily affecting cartilage and the vascular system.

MGP occurs as four species, i.e. fully carboxylated (cMGP), under-carboxylated, i.e. poorly carboxylated (ucMGP), phosphorylated (pMGP), and non-phosphorylated (desphospho, dpMGP). ELISA methods are currently available that can detect the different species of MGP.

Specificity of RNA expression in 17 cancer types is categorized as either cancer enriched, group enriched, cancer enhanced, low cancer specificity and not detected. The RNA data was used to cluster genes according to their expression across cell lines.

Mar 1, 2017 · Matrix gla protein (MGP), a 15 kDa vitamin K dependent mineral-binding protein found in ECM, has been reported to be synthesized in bone, and to be expressed at lower levels in cartilage, liver, kidney, lung, heart, and vascular smooth muscle cells (VSMC) [14], [15], [16].

Nov 27, 2024 · Title: Suppression MGP inhibits tumor proliferation and reverses oxaliplatin resistance in colorectal cancer. Intracellular matrix Gla protein promotes tumor progression by activating JAK2/STAT5 signaling in gastric cancer.

Jun 26, 2020 · Our study confirmed that MGP was upregulated in different stages of CC and associated with a worse prognosis. MGP could enrich intracellular free Ca 2+ concentration and promote nuclear factor κB (NF-κB)/p65 phosphorylation, activating the expression of c-MYC, ICAM-1, and VEGFA.