Aug 26, 2022 · Treatment of primary human monocytes with catalytic mTOR inhibitors (mTORi) increased LPS-induced polyfunctional responses, including production of IL-1β, IL-6, and the pro-coagulant, TF.

Aug 26, 2022 · Treatment of primary human monocytes with catalytic mTOR inhibitors (mTORi) increased LPS-induced polyfunctional responses, including production of IL-1β, IL-6, and the pro-coagulant, TF. NF-κB-driven transcriptional activity is enhanced with LPS stimulation after mTORi treatment to increase expression of F3 (TF).

Jul 18, 2018 · Monocyte adhesion is a crucial step in transmigration and can be induced by lipopolysaccharide (LPS). Here, we studied the role of mammalian target of rapamycin (mTOR) complexes, mTORC1 and mTORC2, and PKC in this process.

Our findings show that LPS induces activation of mTOR complexes. This signaling pathway led to integrin expression and cytoskeleton rearrangement resulting in monocyte adhesion. These results describe a new molecular mechanism involved in monocyte adhesion in …

mTOR Inhibition prevents LPS-induced klotho downregulation in vivo. Klotho, as previously described, was originally identified as an anti-aging protein and defects in gene expression have been associated with premature aging syndrome. Renal tubular epithelial cells are identified as the major producer of klotho and its decrease correlated with ...

Dec 1, 2011 · As heightened protein synthesis is the hallmark of many inflammatory syndromes, we hypothesize that the mammalian target of rapamycin (mTOR) pathway, which control the cap-dependent translation initiation phase, was activated by lipopolysaccharide (LPS).

Evidence shows that mTOR may control lysosome tubulation by modulating microtubule motor activity through Arl8b. Macrophages and dendritic cells exposed to lipopolysaccharide (LPS) convert their lysosomes from small, punctate organelles into a network of tubules.

Feb 12, 2020 · Challenging the human lung fibroblast MRC-5 cell line with LPS activated the PI3K-Akt-mTOR pathway, significantly upregulated the expression of 6-phosphofructo-2-kinase/fructose-2,...

Jan 11, 2020 · LPS activates the PI3KI/AKT/MTOR signaling pathway in N9 microglial cells. MTOR signaling is recognized as a major negative regulator of autophagy at its early stage. To explore the deficiency in autophagosome formation caused by LPS in N9 microglial cells, we analyzed upstream MTOR signaling.

May 5, 2017 · In this study we investigated the effects of mTOR inhibition on lipopolysaccharide (LPS)-induced changes on expressions and/or activities of ribosomal protein S6 (rpS6), an mTOR substrate, nuclear factor-κB (NF-κB) p65, inhibitor κB (IκB)-α, inducible nitric oxide synthase (iNOS), cyclooxygenase (COX)-2 with production of nitric oxide ...