In enzymology, an IκB kinase (EC 2.7.11.10) is an enzyme that catalyzes the chemical reaction: Thus, the two substrates of this enzyme are ATP and IκB protein, whereas its two products are …

We describe here how these studies have identified a unique inhibitor of pro-inflammatory NF- κ B signaling, an unforeseen role for IKK α in the classical NF- κ B pathway, and a novel functional …

Composed of two serine-threonine kinases (IKKα and IKKβ) and the regulatory subunit NEMO (also known as IKKγ), the IKK complex integrates signals from all NF-κB activating stimuli to …

Inhibitory kappa B kinase beta (IKKβ), known as IKK2, is a key regulatory kinase responsible for the activation of NF-κB through its phosphorylation at Ser177 and Ser181 to promote the …

Control over the immune cell functions of NF-κB results from signaling through one of two different routes: the canonical and noncanonical NF-κB signaling pathways. Present at the end of both …

Nov 22, 1999 · Rel/NF-κB transcription factors are primarily regulated by association with inhibitor IκB proteins. Thus, in most cells NF-κB exists in the cytoplasm in an inactive complex bound to …

Oct 17, 1997 · Recently we purified a 900 kDa cytokine-responsive IκB kinase complex (IKK) and molecularly cloned one of its subunits, IKKα, a serine kinase. We now describe the molecular …

New work reveals the roles of the three subunits of IKK and how it is regulated. NF-κB represents a family of transcription factors that are normally kept inactive in the cytoplasm through …

Feb 26, 2008 · We proposed that NF-κB transcription factors regulated via the IκB kinase (IKK) complex play a critical role in coupling inflammation and cancer and have set out to test this …

Dec 27, 2013 · Composed of two serine‐threonine kinases (IKK α and IKK β) and the regulatory subunit NEMO (also known as IKK γ), the IKK complex integrates signals from all NF ‐κB …