May 3, 2018 · Here, we show that cellular stress disrupts nucleocytoplasmic transport by localizing critical nucleocytoplasmic transport factors into stress granules, RNA/protein …

Apr 26, 2023 · We identify that toxic dipeptide repeats produced in ALS/FTD conditions activate JNK. The activated JNK in the nucleus can induce histone modifications which increase …

‪Junior Principle Investigator, Shenzhen Bay Laboratory‬ - ‪‪Cited by 4,704‬‬ - ‪Neurodegenerative diseases‬

张轲博士在 Nature, Science, Cell, Neuron, Nature Cell Biology 等国际著名期刊上发表研究论文24篇。 其中以第一作者或通讯作者发表文章 10 篇（包括Nature 2篇，Cell 1 篇等）。 总共引 …

Aug 26, 2015 · The hexanucleotide repeat expansion (HRE) GGGGCC (G4C2) in C9orf72 is the most common cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).

c-Jun N-Terminal Kinase Promotes Stress Granule Assembly and Neurodegeneration in C9orf72-Mediated ALS and FTD Sahana, T. G., Chase, K. J., Liu, F., Lloyd, T. E., Rossoll, W. & Zhang, …

Sep 3, 2015 · Nucleocytoplasmic transport defects may be a fundamental pathway for ALS and FTD that is amenable to pharmacotherapeutic intervention. The hexanucleotide repeat …

2019 Frick Foundation for ALS Research Award. 2018 Springboard Fellowship Award, Target ALS Consortia. 2016 The Helen Taussig Young Investigator Award, Johns Hopkins School of …

Apr 28, 2022 · Here, we show that ER stress activates JNK via IRE1 in fly and cellular. ALS/FTD. Furthermore, activated JNK promotes SG assembly induced by poly(GR) and. a key SG …

May 3, 2018 · Our findings identify a link between stress granule assembly and nucleocytoplasmic transport, two fundamental cellular processes implicated in the pathogenesis of C9ORF72 …