Anti-Jo-1 autoantibody is the most frequently detected anti-aaRS antibody in ASSD and targets the histidyl tRNA synthetase which catalyses the binding of the histidine to its cognate tRNA during protein synthesis. (4,5).

In this study we focus on anti-Jo-1 (histidyl-tRNA synthetase). This autoantibody is associated with inflammatory muscle diseases and interstitial lung diseases (ILD). We retrospectively identified a cohort of patients tested for the panel of anti-ENA autoantibodies in our hospital.

Anti-Jo-1 antibody is a myositis- specific autoantibody most commonly found in patients with idiopathic inflammatory myopathies (IIM). Presence of Jo-1 (antihistidyl transfer RNA [t-RNA] synthetase) antibody is associated with polymyositis and may also be seen in patients with dermatomyositis.

Anti-Jo1 is an anti-nuclear antibody. [1][2] Anti-Jo1 has been associated with inflammatory myopathies such as polymyositis, dermatomyositis and antisynthetase syndrome. [3][4] It has histidine-tRNA ligase as a target.

Evaluating patients with clinical features of idiopathic inflammatory myositis, especially those with clinical features suggestive of anti-synthetase syndrome or interstitial lung disease. For more information see Connective Tissue Disease Cascade. Multiplex Flow Immunoassay.

Anti-Jo-1 is the most common autoantibody seen in antisynthetase syndrome and is present in an estimated 70-90% of patients with Myositis who have associated Interstitial Lung Disease.

Anti-Jo-1 antibody is a myositis specific autoantibody most commonly found in patients with idiopathic inflammatory myopathies (IIM). This antibody is directed against the histidyl-tRNA synthetase which catalyses the binding of the histidine …

Anti-Jo-1 Ab (RDL), or Anti-Histidyl-tRNA Synthetase Antibody, is a pivotal serological marker extensively used in the diagnosis and management of autoimmune disorders, particularly Idiopathic Inflammatory Myopathies (IIM), including Polymyositis (PM) and Dermatomyositis (DM).

Jul 20, 2024 · Anti-Jo-1 antibody is a myositis specific autoantibody most commonly found in patients with idiopathic inflammatory myopathies (IIM). This antibody is directed against the histidyl-tRNA synthetase which catalyses the binding of the histidine to its cognate tRNA during protein synthesis.

Jo-1 is an autoantibody that recognizes a cytoplasmic protein, histidyl-tRNA synthetase, an enzyme important for incorporating histidine into proteins. 58 Jo-1 is a marker of immune-mediated ILD and may be helpful in its early evaluation. 59,60 ANA may be negative in patients positive for Jo-1, although granular histidyl-tRNA synthetase ...