Like other members of the JIP family of scaffold proteins, JIP4 binds JNK and also the light chain of the microtubule motor protein kinesin-1. However, the function of JIP4 appears to be markedly different from other JIP proteins. Specifically, JIP4 does not activate JNK signaling.

The c-Jun NH2-terminal kinase (JNK)-interacting protein (JIP) group of scaffold proteins (JIP1, JIP2, and JIP3) can interact with components of the JNK signaling pathway and potently activate JNK. Here we describe the identification of a fourth ...

JIP‐4 and SPAG9 show fundamental differences in organ expression. JIP‐4 is mainly expressed in the brain, heart, liver, kidney and testis, whereas SPAG9 is only expressed in haploid germ cells during spermatogenesis.

JIP-4 Antibody (H-8) is an IgG κ mouse monoclonal JIP-4 antibody (also designated JIP-4 antibody) that detects the JIP-4 protein of mouse, rat and human origin by WB, IP, IF, IHC (P) and ELISA.

A gene on chromosome 17q21.33 that encodes sperm-associated antigen 9, a member of the JNK-interacting protein (JIP) group of scaffold proteins, which selectively mediates JNK signalling by aggregating specific components of the MAPK cascade to …

Mar 30, 2025 · SPAG9 (Sperm Associated Antigen 9) is a Protein Coding gene. Diseases associated with SPAG9 include Retinitis Pigmentosa 42 and Subacute Leukemia. Among its related pathways are Akt Signaling and Nervous system development. Gene Ontology (GO) annotations related to this gene include kinesin binding and MAP-kinase scaffold activity.

Jul 20, 2021 · Here, we report that JIP4 (officially known as SPAG9), a protein previously described to bind to microtubule motors, is recruited to tubulating subdomains on macropinosomes by the PtdIns3P-binding protein Phafin2 (officially known as PLEKHF2).

Here, we outline recent findings on the mechanisms of lysosomal trafficking by focusing on adapter protein c-Jun NH 2 -terminal kinase-interacting protein (JIP) 4, which plays a central role in this process, and other JIP4 functions and JIP family proteins.

The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed: 14743216).

Jan 2, 2013 · Using phosphoproteome arrays, we observed strong induction of JNK2 phosphorylation potentially resulting from cetuximab-inhibited EGFR through c-jun-NH 2 -kinase (JNK)-interacting protein-4 (JIP-4), which was identified using an immunoprecipitation-mass spectrometric approach.