Intraretinal microvascular abnormality (IRMA) – Right circle on image. These are small abnormally shaped blood vessels that shunt blood from arterioles to venules. They characteristically do not leak on FA, unlike neovascularization elsewhere (NVE). Mild NPDR: 1 microaneurysm or more (and no other features!) Severe NPDR: Use the 4-2-1 rule below.

The anatomical location of these lesions is crucial for differentiation of non-proliferative vs. proliferative lesions (hemorrhages vs. preretinal hemorrhages and IRMA vs. NVE in particular). Microaneurysms (Ma’s) – Ma’s are the first lesions appearing in diabetic retinopathy.

Intraretinal microvascular abnormalities (or IrMAs) are shunt vessels and appear as abnormal branching or dilation of existing blood vessels (capillaries) within the retina that act to supply areas of non-perfusion in diabetic retinopathy.

Aug 16, 2016 · The WESDR stated that moderate NPDR contains dot blot hemorrhages (DBH) or microaneurysms (MA) as numerous and severe as the standard photo 2A below in at least one quadrant, with or without cotton wool spots (CWS), venous beading, or …

For some lesions (HMA and IRMA) the severity of the lesion is defined by comparison with photographic standards, and, in the cases of HMA, by the areal extent of the lesion. For determining areal extent, the image field is mentally divided by a horizontal line passing through the macula and the optic disc into upper hemifield and lower hemifield.

Optical coherence tomography angiography, through flow overlay, has utility to image and differentiate IRMA and NV, which are key features distinguishing severe non-PDR and PDR, respectively. Noninvasive widefield OCTA may be a useful tool to diagnose high-risk diabetic retinopathy eyes.

Mar 7, 2024 · Intraretinal microvascular abnormalities (IRMAs) refer to a potential complication of diabetic retinopathy. Damage may start to occur in the blood vessels of the eyes if a person experiences...

Jun 8, 2023 · When that goes on too long, you can develop intraretinal microvascular abnormalities (IRMAs), the name for specific changes in the blood vessels. IRMAs can indicate that diabetic retinopathy...

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In this study, we identified several OCT-derived parameters that distinguish IRMAs and NVEs. We suggest that current clinical and FA definitions of IRMA vs NVE should be supported with SD OCT findings.