Vitamin B6 (Pyridoxine) supplementation can decrease odds of peripheral neuropathy in persons who are pregnant or breast feeding, or who have HIV, renal failure, alcoholism, diabetes, or underlying peripheral neuropathy. B6 should be given to exclusively breastfed infants on INH. Neutropenia (very rare)

Aug 8, 2023 · Isoniazid (INH) can interfere with vitamin B6 metabolism and result in a deficiency. Patients receiving INH for the treatment of tuberculosis should be supplemented with vitamin B6. Dose recommendations range from 6 to 50 mg daily as prophylaxis to 100 to 200 mg if neurotoxicity and documented vitamin B6 deficiency develop, especially in ...

Prescribe Vitamin B6 (pyridoxine) at 25 mg/day to decrease peripheral and CNS effects and for patients with chronic alcohol or who are pregnant, breastfeeding3 or or have HIV, cancer, diabetes, chronic kidney or liver disease, or preexisting peripheral neuropathy.

Feb 28, 2024 · Isoniazid (INH) is a potent bactericidal antibiotic prescribed for tuberculosis (TB). Treatment with INH therapy has a risk of toxicity, which is acute or chronic, leading to long-term liver damage if not appropriately treated.

Treatment regimens for latent TB infection (LTBI) use isoniazid (INH), rifapentine (RPT), or rifampin (RIF). CDC and the National Tuberculosis Controllers Association preferentially recommend short-course, rifamycin-based, 3- or 4-month latent TB infection treatment regimens over 6- or 9-month isoniazid monotherapy.

Vitamin B6 (pyridoxine) supplementation during isoniazid (INH) therapy is necessary in some patients to prevent the development of peripheral neuropathy.

Jun 9, 2000 · Pyridoxine (vitamin B6), 25-50 mg/day, is given with INH to all persons at risk of neuropathy (e.g., pregnant women; breastfeeding infants; persons with HIV; patients with diabetes, alcoholism, malnutrition, or chronic renal failure; or patients with advanced age).

Short-course treatment regimens, like 3HP and 4R, are effective, safe, and have higher completion rates than longer 6 to 9 months of isoniazid monotherapy (6H/9H). Shorter, rifamycin-based treatment regimens generally have a lower risk of hepatotoxicity than 6H and 9H.

Oct 11, 2023 · Isoniazid, a potent anti-tuberculosis medication, disrupts the body’s utilization of vitamin B6, also known as pyridoxine, through a multifaceted process. Isoniazid interferes with the conversion of pyridoxine (a precursor of vitamin B6) into its active form, pyridoxal phosphate.

The CDC guidelines for LTBI treatment states that Vitamin B6 is clinically indicated while taking INH to prevent peripheral neuropathy for patients with the following conditions. Please select all that apply: