Nov 19, 2019 · Here we discuss the central role of IL-7 and IL-7R in the lymphoid system and highlight the impact of their deregulation, placing a particular emphasis on their ‘dark side’ as promoters of...

Interleukin-7 receptor is expressed on various cell types, including naive and memory T cells and many others. Interleukin-7 receptor has been shown to play a critical role in the development of immune cells called lymphocytes - specifically in a process known as V (D)J recombination [citation needed].

IL-7/IL-7R have dual roles in the development of cancer, and exploring the IL-7R-mediated signaling pathways has shown good therapeutic effects in both liquid tumors and some solid tumor models, indicating a promising future for inhibiting tumor occurrence.

The cytokine IL-7 and its receptor, IL-7R, are critical for T cell and, in the mouse, B cell development, as well as differentiation and survival of naive T cells, and generation and maintenance of memory T cells.

Expression of IL-7 and IL-7R in RA monocytes is linked to disease activity score and TNF transcription. TNF stimulation can modulate IL-7 secretion and IL-7R frequency in myeloid cells, however, only IL-7R transcription levels are downregulated in anti-TNF responsive patients.

Interleukin 7 (IL-7) is a protein [5] that in humans is encoded by the IL7 gene. [6] [7] [8] IL-7 is a hematopoietic growth factor secreted by stromal cells in the bone marrow and thymus. It is also produced by keratinocytes, [9] follicular dendritic cells, [10] hepatocytes, [11] neurons, and epithelial cells, [12] but is not produced by normal ...

Mar 30, 2025 · IL7R (Interleukin 7 Receptor) is a Protein Coding gene. Diseases associated with IL7R include Immunodeficiency 104, Severe Combined and T-B+ Severe Combined Immunodeficiency Due To Il-7Ralpha Deficiency. Among its related pathways are TGF-Beta Pathway and Akt Signaling.

Dec 12, 2019 · IL-7R expression is a functional biomarker of T-ALL cells with leukemia-initiating potential and plays a crucial role in T-ALL pathogenesis. Targeting IL-7R–mediated signaling hampers leukemia-initiating activity and progression of human T-ALL.

Dec 2, 2021 · Deficiencies in IL-7 or IL-7R can lead to severely impaired immune cell development (Table 1). In the ensuing decades, the discovery of relevant signaling pathways was accompanied by recognition that IL-7 plays an indispensable role in the development and maintenance of many other immune cells.

In this review, we focus on the emerging details on the developmentally regulated spatial distribution of IL-7 in vivo that controls all IL-7 receptor (IL-7R) expressing cell subsets with tissue specific and systemic functions in immunity, with a particular emphasis on …