The IL-5 receptor (IL-5R) belongs to the type I cytokine receptor family and is a heterodimer composed of two polypeptide chains, one α subunit, which binds IL-5 and confers upon the receptor cytokine specificity, and one β subunit, which contains the signal transduction domains.

IL-5Rα expression in activated B cells is regulated by a complex of transcription factors including E12, E47, Sp1, c/EBPβ, and Oct2. IL-5 signals are transduced through JAK–STAT, Btk, and Ras/Raf-ERK signaling pathways and lead to maintenance of survival and functions of B …

A human high affinity interleukin-5 receptor (IL5R) is composed of an IL5-specific alpha chain and a beta chain shared with the receptor for GM-CSF. Cell. 1991 Sep 20;66(6):1175–1184. doi: 10.1016/0092-8674(91)90040-6.

Jan 8, 2019 · Anti-interleukin-5 therapy is approved for patients with refractory asthma with an eosinophilic phenotype. The severe asthma care team at Mayo Clinic has expertise in identifying appropriate patients for this step-up therapy.

Monoclonal antibodies that target the eosinophilic inflammatory pathways (IL‐5R and IL‐5), namely mepolizumab, reslizumab, and benralizumab, are effective and safe for severe eosinophilic asthma. Eosinophils threshold represents the most indicative biomarker for response to treatment with all three monoclonal antibodies.

Sep 20, 1991 · cDNA clones encoding two receptor proteins involved in the binding of human interleukin 5 (hIL5) have been isolated. A first class codes for an IL5-specific chain (hIL5Rα).

Sep 20, 1991 · A first class codes for an IL5-specific chain (hIL5R alpha). The major transcript of this receptor gene, as analyzed in both HL-60 eosinophilic cells and eosinophilic myelocytes grown from cord blood, encodes a secreted form of this receptor. This soluble hIL5R alpha has antagonistic properties.

Dec 7, 2011 · To investigate the mechanism underlying ligand-receptor recognition, we determined the structure of IL-5 bound to the extracellular domain of IL-5Rα. IL-5 makes contact with all three fibronectin III-like domains of IL-5Rα, with …

Human interleukin 5 receptor (IL5R ) comprises three fibronectin type III domains (D1, D2, and D3) in the extracellular region. Previous results have indi-cated that residues in the D1D2 domains are crucial for high affinity interaction with human interleukin 5 (IL5).

IL-5在嗜酸性粒细胞的成熟、活化、增殖和存活中发挥核心作用，是治疗嗜酸性粒细胞性哮喘的关键靶点。 嗜酸性粒细胞中IL-5激活的分子机制和信号通路。 IL-5与其受体 (IL-5Rα)的α亚基结合可诱导由α和βc亚基组成的二聚体受体复合物的组装。 随后几个信号通路的激活，包括 JAK/STAT 、 MAPK 、 PI3K 和 NF-κB，负责参与嗜酸性粒细胞分化、脱颗粒、存活、增殖、趋化和粘附的基因的转录 [2]。 抗IL-5/IL-5R生物疗法。 旨在抑制嗜酸性粒细胞功能的单克隆抗体包括结合并中 …