Jan 24, 2013 · We report that IL-7 and IL-15 support the generation of postmitotic costimulated CD8 + T cells with molecular and functional features of T SCM cells.

Here we show that IL-7 and IL-15 are required to maintain human T cell proliferative capacity through the STAT5 signaling pathway. T cells from humanized mice proliferate better if …

Cytokines IL-2, IL-7 and IL-15 have been found to stimulate the growth of T cells, however, the optimized combination of these three cytokines for T cell proliferation is unknown. In this study, …

Cytokines IL-7 and IL-15 are essentially involved in T-cell homeostasis. IL-7 is required for developing mature T cells in the thymus, whereas in the periphery, it promotes the survival of …

Oct 22, 2020 · Transcriptomic data analysis identified the genes and transcriptional regulators up/down-regulated by each of the cytokines IL-2, IL-7, and IL-15. It was found that the genes …

May 31, 2024 · We propose that IL-7 and IL-15 collaborate to support memory CD8 + T cells in homeostasis, not only via redundancy (as both strongly activate STAT5 as well as other …

Apr 29, 2010 · In a xenogeneic adoptive transfer model, we have compared the therapeutic potency of CD19-specific human primary T cells that constitutively express interleukin-2 (IL-2), …

Nov 1, 2008 · We find that IL-7 and IL-15 differentially regulate CD8 + T-cell subsets defined by KLRG1 and CD127 expression during the contraction phase of the immune response.

Sep 1, 2016 · This review explores the differential roles of the cytokines interleukin (IL)-2, IL-7, and IL-15 in the regulation of T helper cell subset specification and the potential flexibility …

Nov 1, 2008 · The provision of IL-15, or the related cytokine IL-2, during contraction led to the preferential accumulation of KLRG1(hi)CD127(lo) CD8+ T cells, whereas provision of IL-7 …