Mar 5, 2021 · Interleukin-10 (IL-10) is a multifunctional cytokine which has been seen to play a relevant role in the pathogenesis of sepsis. We examined the association between a single nucleotide polymorphism (SNP) in IL-10-1082G/A in patients with sepsis in Cali city. Methods.

Nov 26, 2019 · We found that the C/T or T/T and C/A or A/A genotypes of IL10 -819 and IL10-592, respectively, increased 1.23 times the risk of developing DLBCL in relation to the patients that had the C/C genotypes in the both SNPs.

Single-nucleotide polymorphisms (SNPs) in the IL-10 gene promoter have been described to contribute to risk for NHL [22 – 25]. A well-studied SNP in the IL-10 promoter is the IL-10-1082 G →A allele (IL-10-1082) SNP [26 – 30].

Cytokines encoded by the interleukin-10 gene (IL10) family have broad immunomodulatory function in viral persistence, and several SNPs in the IL10 promoter sequence have been reported to influence pathogenesis or acquisition of HIV-1 infection.

Interleukin-10 (IL-10) is a dominant cytokine in the regulation of immunity to infection, as it suppresses macrophages and dendritic cells (DCs), thereby limiting T helper type 1 (T H 1) and T helper type 2 (T H 2) effector responses (3).

The IL-10 (-1082) G → A polymorphism (IL-10 SNP) is associated with improved survival in certain non-CNS lymphoma patients. PDCD4 is a tumor suppressor gene and upstream regulator of IL-10.

In fact, IL-10 production levels can be stratified from low to high which is based on SNP haplotype blocks upstream of IL10 [122–124]. This may make evolutionary sense, as evidence suggests that the IL10 locus is under selective pressure from various pathogens [125, 126].

Jan 23, 2022 · However, the disease susceptibility and abnormal function of the mutated IL-10 variants remain obscure. In this study, we used seven bioinformatics tools (SIFT, PROVEAN, PMut, PANTHER, PolyPhen-2, PHD-SNP, and SNPs&GO) to predict the disease susceptible non-synonymous SNPs (nsSNPs) of IL-10.

One microsatellite and three single nucleotide polymorphisms (SNPs) have been recorded within the 1.2 kb immediately upstream of the gene, with an additional microsatellite present at 4 kb upstream. The relationship between these two classes of polymorphism is poorly defined in …

Feb 26, 2024 · One of the most well-studied single nucleotide polymorphisms (SNP) of IL10, rs1800896 (−1082 G/A), is in the promotor region and the A allele (the major allele) carriers have been associated with AD [25] and the presence of AD pathology [1].