Apr 22, 2019 · Through the use of mouse models of melanoma and thymoma, the authors show that the deletion of IL-10 and/or IL-35 in T reg cells leads to reduced tumor growth and a drastic reduction in...

May 24, 2021 · Our results provide preclinical evidence that IL-10–Fc is a safe and highly effective therapy that acts on a specific subset of CD8 + TILs distinct from those responding to ICBs. Thus,...

The expansion and activation of tumor antigen reactive CD8+ T cells are primary goals of immunotherapies for cancer. IL-10 is an anti-inflammatory cytokine with an essential role in the development and proliferation of regulatory T cells, ...

Jun 10, 2019 · Increasing evidence demonstrates that interleukin-10 (IL-10), known as an immunosuppressive cytokine, induces antitumor effects depending on CD8 + T cells. However, it remains elusive how immunosuppressive effects of IL-10 contribute to CD8 + T cell-mediated antitumor immunity.

Smith et al. demonstrate that during chronic infections, IL-10 upregulates N-glycan branching on CD8+ T cell surface glycoproteins, which reduces signal transduction downstream of the T cell receptor and decreases CD8+ T cell antigen sensitivity and capacity to control pathogen burden.

Jun 1, 2006 · Here, we show that regulatory function can be rapidly induced in class I–restricted CD8 cells, resulting in potent contact-dependent suppression combined with IL-10 production. Transfer of CD8 Tregs into mice blocked antigen-specific antibody responses and graft-versus-host disease (GVHD).

Interleukin-10-Fc was a safe and highly efficient metabolic intervention that synergized with adoptive T cell transfer immunotherapy, leading to eradication of established solid tumors and durable cures in the majority of treated mice.

Nov 15, 2017 · Blocking IL-10 resulted in higher apoptosis, fewer IFN-γ + CD8 + T cells, and lower Bcl-2 expression. IL-10 also significantly increased STAT3, but not STAT1, phosphorylation in CD8 + T cells. Together, these results suggested that IL-10 could enhance CD8 + T cell inflammation in DLBCL patients.

Mar 15, 2011 · In this article, we show that IL-10, a potent anti-inflammatory cytokine, is produced transiently at the peak of infection by CD8 T cells in the brains of coronavirus-infected mice. IL-10 (+)CD8 and IL-10 (-)CD8 T cells interconvert during acute disease, possibly based on …

Feb 15, 2024 · JAK1-STA6 signaling pathway regulates IL-10 expression in CD8 + T cells. IL-10 enhances the function of CD8 +T cells through JAK3-STAT6 signaling pathway. IL-10 is a pleiotropic cytokine that plays a significant role in antiviral and antitumor immunity.