Interleukin 17 family (IL17 family) is a family of pro-inflammatory cystine knot cytokines. [2] . They are produced by a group of T helper cell known as T helper 17 cell in response to their stimulation with IL-23. Originally, Th17 was identified in 1993 by Rouvier et al. who isolated IL17A transcript from a rodent T-cell hybridoma. [3] .

Interleukin-17 (IL-17, also known as IL-17A) is a key cytokine that links T cell activation to neutrophil mobilization and activation. As such, IL-17 can mediate protective innate immunity to pathogens or contribute to the pathogenesis of ...

Here, we discuss the functions of the IL-17 family, with a focus on the balance between the pathogenic and protective roles of IL-17 in cancer and autoimmune disease, including results of therapeutic blockade and novel aspects of IL-17 signal transduction regulation.

Oct 11, 2023 · Interleukin 17 (IL-17) is an important cytokine that has several roles in host defense responses against mucosal infections; additionally, it is a primary pathologic cytokine and therapeutic...

Mar 22, 2024 · IL-17 inhibitors block the inflammatory pathway of interleukin-17A. These biologic medications are an extremely effective FDA-approved treatment option for people with psoriasis and psoriatic arthritis.

Interleukin-17 (IL-17) and IL-17-producing cells have been shown to play important roles in inflammation and the immune response. IL-17 is believed to be mainly produced by T helper 17 (Th17) cells, a unique helper T-cell subset different from Th1 and Th2 cells.

The interleukin 17 (IL-17) family, a subset of cytokines consisting of IL-17A-F, plays crucial roles in host defense against microbial organisms and in the development of inflammatory diseases.

Jan 1, 2020 · Interleukin 17 (IL-17) is a proinflammatory cytokine that has been the focus of intensive research because of its crucial role in the pathogenesis of different diseases across many medical specialties.

Nov 19, 2019 · IL-17 is a highly versatile pro-inflammatory cytokine crucial for a variety of processes, including host defense, tissue repair, the pathogenesis of inflammatory disease and the progression...

Apr 7, 2025 · IL-17 acts on the amygdala to increase anxiety and on the somatosensory cortex to enhance sociability. This suggests a close connection between the immune and nervous systems. IL-17's dual role as ...