IKK-β is an enzyme that serves as a protein subunit of IκB kinase, which is a component of the cytokine-activated intracellular signaling pathway involved in triggering immune responses. IKK's activity causes activation of a transcription factor known as Nuclear Transcription factor kappa-B …

Inhibitory kappa B kinase beta (IKKβ), known as IKK2, is a key regulatory kinase responsible for the activation of NF-κB through its phosphorylation at Ser177 and Ser181 to promote the phosphorylation of inhibitors of kappa B (IκBs), triggering their ubiquitination and degradation to active the nuclear factor kappa-B (NF-κB) cascade.

In enzymology, an IκB kinase (EC 2.7.11.10) is an enzyme that catalyzes the chemical reaction: Thus, the two substrates of this enzyme are ATP and IκB protein, whereas its two products are ADP and IκB phosphoprotein.

IKKbeta/IKBKB (IkappaB kinase beta), also designated as IKK2, was named after its function of phosphorylating IkappaB molecules, the inhibitors of NF-kappaB transcription factors. The kinase activity of IKKbeta targets two adjacent serine residues of …

IKKα and IKKβ show a similar structure (50% sequence identity), and include an amino-terminal kinase domain, a helix-loop-helix (HLH) that functions in modulating IKK kinase activity, and a leucine zipper (LZ), whose role is to allow homo- or heterodimerization of the kinases (Fig. 1).

1 day ago · IKKβ Antibody detects endogenous levels of total IKKβ protein. The antibody does not cross-react with endogenous levels of IKKα or IKKγ. Human, Monkey. Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues at the carboxy terminus of human IKKβ.

IkB subunit beta (IKKβ) is one of the three kinases in IKK which is a convergence point for many NF-κB signaling pathways (11, 13). Alterations of NF-kB signaling dynamics has been demonstrated as a function of inhibiting IKK action (14–17).

N-acetyl-seryl-aspartyl-lysyl-proline inhibition of TNF-alpha activation of canonical, i.e., IKK-beta-dependent, NF-kappaB pathway and subsequent decrease in ICAM-1 expression is achieved via inhibition of IKK-beta.

This study evaluates the effects of pathway inhibitors on early NF-κB activity and downstream gene transcription. 3T3 fibroblasts were treated with SC-514, an inhibitor targeted to the NF-kB pathway, prior to stimulation with interleukin 1 beta (IL-1β) or tumor necrosis factor alpha (TNF-α).

Mar 30, 2025 · IKBKB (Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta) is a Protein Coding gene. Diseases associated with IKBKB include Immunodeficiency 15B and Immunodeficiency 15A. Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and TNFR1 Pathway.