Interleukin 8 (IL-8 or chemokine (C-X-C motif) ligand 8, CXCL8) is a chemokine produced by macrophages and other cell types such as epithelial cells, airway smooth muscle cells [3] and endothelial cells.

Interleukin-8 (IL-8) is a chemoattractant cytokine produced by a variety of tissue and blood cells. Unlike many other cytokines, it has a distinct target specificity for the neutrophil, with only weak effects on other blood cells.

Interleukin-8 is a potent cytokine that acts as a chemoattractant for neutrophils and is produced by various tissue and blood cells, including cardiac myocytes and endothelial cells. AI generated definition based on: European Journal of Pharmacology, 2001

May 1, 2022 · We extensively studied the regulation of IL-8 gene transcription by IL-1, TNFα, PMA + ionomycin, TNFα + IFNγ, and LPS in several types of cells and identified NF-κB in combination with AP-1 or C/EBP to synergistically activate IL-8 gene expression.

Interleukin (IL)-8 is a secretory product of stimulated macrophages and other cells and was the first CXC chemokine to be discovered and characterized. [8 – 10] It is a potent chemoattractant for neutrophils both in vitro and in vivo and comprises part of the inflammatory exudate induced by microbial infection in vivo. [11, 12] Truncation of ...

Interleukin-6 (IL-6) is an acknowledged inflammatory cytokine with a pleiotropic action, mediating innate and adaptive immunity and multiple physiological processes, including protective and regenerative ones. IL-8 is a pro-inflammatory CXC ...

Jul 7, 2021 · Interleukin-8 is a chemotactic agent for monocytes and neutrophils. Interleukin 8 causes oxygen radical and enzyme release by neutrophils and mobilizes products into circulation.

IL-8 was first identified in 1987 as a potent, proinflammatory chemokine, which induces trafficking of neutrophils across the vascular wall (chemotaxis) (Table 58-16).121 This molecule belongs to a chemokine superfamily whose members include neutrophil-activating peptide-2, platelet factor-4, growth-related cytokine (GRO) (also known as ...

IL-8 was initially characterized as a chemoattractant of neutrophils engaged in acute inflammation and then discovered to also be chemotactic for endothelial cells with a major role in angiogenesis. These two activities of IL-8 foster its stimulatory effect on tumor growth.

Interleukin-8 (IL-8), a member of the CXC chemokine family, is an important activator and chemoattractant for neutrophils and has been implicated in a variety of inflammatory diseases.