Jan 8, 2015 · Interleukin-6 (IL-6) is one of the most critical tumor-promoting cytokines in non-small cell lung cancer (NSCLC). In our recent study, we confirmed that NADPH oxidase 4 (NOX4), an important source of reactive oxygen species (ROS) production in NSCLC cells, promotes malignant progression of NSCLC.

Selective NOX1 inhibition rescues age-impaired blood flow and angiogenesis, abrogates senescence, and restores vascular function. NF-κB and peroxisome proliferator–activated receptor gamma counter-regulate NOX1; and IL-6 and NOX1 are central to a degenerative spiral.

Secretion of the TH1-promoting cytokine IL-12 and other pro-inflammatory cytokines including IL-6, Tumor necrosis factor (TNF) and IL-1β is inhibited by NOX2 [50,75,127,129,130].

Oct 19, 2021 · In an inquiry into signaling triggered by aging and proxy instigator, hyperglycemia, we show that NADPH Oxidase (NOX) drives cell DNA damage and alters nuclear envelope integrity, inflammation, tissue dysfunction, and cellular senescence in mice and humans with similar causality.

IL-6 has direct effects on endothelial nitric oxide synthase activity and expression as well as increasing vascular superoxide, which rapidly inactivates NO thereby limiting NO bioavailability.

Sep 18, 2018 · Our findings showed that LysoPC-induced COX-2-dependent IL-6 expression is mediated through NOX/ROS/JNK1/2 leading to FoxO1 S256 and NF-κB activation (Fig. 8 d). These results were confirmed by ex vivo studies, indicating the involvement of NOX, NF-κB, or FoxO1 in LysoPC-mediated responses.

Aug 8, 2013 · IL-6 and its effect on the innate and adaptive immune response have been shown to be required for protection against Candida, Yersinia enterocolitica, L. monocytogenes, and M. tuberculosis (24–28) infection, as well as F. tularensis .

Upregulation of NRROS on the hydrogen peroxide (H 2 O 2)-mediated ROS generation and interleukin 6 (IL-6) secretion was measured. 15d-PGJ 2-induced NRROS expression was mediated through PI3K/Akt-dependent activation of Sp1 and FoxO1 and established the essential promoter regions.

Taken together, we demonstrate a constitutive NOX4-dependent ROS generation in a microglial cell line which leads to expression of IL-6 mRNA.

IL-6 is a soluble mediator with a pleiotropic effect on inflammation, immune response, and hematopoiesis. At first, distinct functions of IL-6 were studied and given distinct names based on their biological activity.