IL-6 expression correlates with the onset and severity of acute kidney injury (AKI), but its contribution to pathogenesis remains unclear. This study established a critical role for IL-6 in both the inflammatory response and the resolution of AKI.

IL-6 is a proinflammatory cytokine that has been shown to mediate ischemic AKI [32, 54] and lung injury in mice with AKI . IL-6 can stimulate target cells via a soluble form of the IL-6 Receptor in a process called trans-signaling [ 54 ].

Apr 21, 2017 · IL-6 and Acute Kidney Injury (AKI) Recent studies have shown a close correlation between IL-6 expression and AKI. In ischemic AKI animal model, it was found that IL-6 transcription and signaling are elevated locally and systemically after 60 …

Results: Systemic IL-6 levels increased in AKI patients, especially in hospital admission time, and decreased in parallel with improving renal function. At the same time as IL-6 values increased, there was an increase in FGF23 and a decrease in klotho levels, with a significant and positive correlation between IL-6 and FGF23 levels.

Mar 1, 2019 · Interleukin-6 (IL-6) is an inflammatory cytokine that plays important roles in the inflammatory response and may be useful for predicting the clinical outcomes in patients with AKI. However, supporting evidence adapted to the current KDIGO criteria is lacking.

Nov 1, 2024 · Systemic IL-6 levels increased in AKI patients, especially in hospital admission time, and decreased in parallel with improving renal function. At the same time as IL-6 values increased, there was an increase in FGF23 and a decrease in klotho levels, with a significant and positive correlation between IL-6 and FGF23 levels.

IL-6 was highly expressed in H/R-exposed mRTECs and kidney tissues of AKI mice rendered with renal fibrosis. Knockdown of IL-6 slowed the renal fibrosis after AKI. IL-6 induced DNMT1 to promote FOXO3a promoter methylation and thus inhibited FOXO3a expression.

Mar 13, 2019 · Kidney diseases are commonly divided into two major groups based on the duration of the disease, i.e. acute kidney injury (AKI) and chronic kidney disease (CKD). IL-6 cytokine family members have been implicated in both AKI and CKD (Figure 2).

Interleukin-6 (IL-6) is a proinflammatory cytokine that increases early in the serum of patients with acute kidney injury (AKI). The aim of this study was to determine whether urine IL-6 is an early biomarker of AKI and determine the source of urine IL-6.

Aug 1, 2022 · The current results demonstrated the pro-fibrotic property of IL-6 in the kidney tissues after AKI by regulating the DNMT1/FOXO3a/Wnt/β-catenin axis, highlighting the promise of novel targets for preventing its progression to chronic kidney disease.