In enzymology, an IκB kinase (EC 2.7.11.10) is an enzyme that catalyzes the chemical reaction: Thus, the two substrates of this enzyme are ATP and IκB protein, whereas its two products are ADP and IκB phosphoprotein.

Feb 25, 2010 · The experiments suggest that IKKalpha will be a therapeutic target in inflammatory disorders. These results demonstrate the importance of IKKalpha in canonical NF-kappaB activation, downstream of cytokine treatment of cells.

Feb 25, 2010 · Using cells from mice that are genetically deficient in IKKβ or IKKα, or using a kinase inactive mutant of IKKβ, it has been proposed that IKKβ is critical for TNF-induced IκB phosphorylation/degradation through the canonical pathway while IKKα has been shown to be involved in the non-canonical pathway for NF-κB activation.

The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation. Cell. 1997;91:243–52. doi: 10.1016/s0092-8674(00)80406-7.

Oct 22, 2008 · IkappaB kinase alpha (IKKalpha), one of the two catalytic subunits of the IKK complex involved in nuclear factor kappaB (NF-kappaB) activation, also functions as a molecular switch that controls epidermal differentiation.

Apr 28, 2005 · Here we describe a new role for IKKalpha in the negative regulation of macrophage activation and inflammation. IKKalpha contributes to suppression of NF-kappaB activity by accelerating both the turnover of the NF-kappaB subunits RelA and c-Rel, and their removal from pro-inflammatory gene promoters.

IκB kinase (IKK)/Nuclear factor kappa B (NF-κB) family signaling mediates the expression of hundreds of genes involved in inflammation, immune response, cell survival, and cancer [1 - 4].

Jan 18, 2021 · We propose a model in which IKKα phosphorylates c-Myc at serine-67 and serine-71 in the nucleus, leading to subsequent inhibition of GSK3β (glycogen synthase kinase 3β) mediated phosphorylation, which is important for degradation of c-Myc, thus stabilizing c-Myc and enhancing its transcriptional activation, thereby increasing proliferation and i...

Using cells from mice that are genetically deficient in IKKβ or IKKα, or using a kinase inactive mutant of IKKβ, it has been proposed that IKKβ is critical for TNF-induced IκB phosphorylation/degradation through the canonical pathway while IKKα has been shown to be involved in the non-canonical pathway for NF-κB activation.

Apr 28, 2005 · Here we describe a new role for IKKα in the negative regulation of macrophage activation and inflammation. IKKα contributes to suppression of NF-κB activity by accelerating both the turnover of...