IGF-1 system has several pleiotropic effects on biological aging (Figure 1). IGF-1 plays a relevant role in fetal development, growth during childhood and adolescence, and adult tissue …

Jun 19, 2018 · Given the conserved role of this pathway on lifespan, therapeutic strategies, such as insulin-like growth factor-1 receptor (IGF-1R) monoclonal antibodies (mAb), represent a …

Secretion of growth hormone (GH), and consequently that of insulin-like growth factor 1 (IGF-1), declines over time until only low levels can be detected in individuals aged ≥60 years. This …

GH/Insulin/insulin-like growth factor 1 (IGF-1) signaling molecules that have been linked to longevity include daf-2 and InR and their homologues in mammals, and inactivation of the …

Moreover, mice as well as humans with reduced activity of the GH/IGF-1 axis are protected from cancer and diabetes mellitus, two major ageing-related morbidities. Here, we review data on …

5 days ago · This study demonstrates that chronic activation of IGF-1 signaling leads to aging-associated senescence at the cellular and organ levels, accompanied by p53-dependent …

The insulin-like growth factor-1 (IGF-1) signaling pathway is known as a potent aging modifier, disruption of which consistently associates with lifespan extension across diverse species. …

Apr 5, 2012 · Paradoxical effects of insulin-like growth factor (IGF)-1 on atherogenesis and the aging process. IGF-1 blunts multiple processes (in box, left) that are relevant to …

Mar 27, 2025 · Alzheimer’s disease (AD) is a leading cause of dementia, characterized by multifactorial interactions involving genetic, inflammatory, and metabolic dysregulation. Insulin …

Mar 27, 2025 · With aging, IGF-1 declines alongside GH output, contributing to muscle loss, decreased bone density, and cognitive decline. Lower IGF-1 levels in older adults increase the …