5 days ago · HSP90AA1 (Heat Shock Protein 90 Alpha Family Class A Member 1) is a Protein Coding gene. Diseases associated with HSP90AA1 include Hematologic Cancer and Candidiasis . Among its related pathways are Drug-mediated inhibition of ERBB2 signaling and Loss of Nlp from mitotic centrosomes .

The gene, HSP90AA1, encodes the human stress-inducible 90-kDa heat shock protein alpha (Hsp90A). Complemented by the constitutively expressed paralog Hsp90B which shares over 85% amino acid sequence identity, Hsp90A expression is initiated when a cell experiences proteotoxic stress.

Feb 19, 2025 · Data show that the heat shock protein 90 (HSP90) isoforms HSP90AA1 and HSP90AB1 are responsible for maintaining proper cellular levels of BMAL1 protein. extracellular Hsp90alpha promotes angiogenesis in an MMP-2-dependent manner.

Heat shock protein 90α (Hsp90α), encoded by the HSP90AA1 gene, is the stress inducible isoform of the molecular chaperone Hsp90. Hsp90α is regulated differently and has different functions when compared to the constitutively expressed Hsp90β ...

Mar 16, 2025 · Positional proteomics analysis identifies the cleavage of human heat shock protein 90kDa alpha (cytosolic), class A member 1 (HSP90AA1) at amino acid residues 473-474 and 491-492 by the HIV-1 protease

Feb 8, 2025 · Hsp90 is involved in cAMP-induced diffentiation of primary Schwann cells in rats. It stabilizes ErbB2 and promotes nuclear translocation of Gab1 and ERK. Hsp90 is involved in the activation of the Raf/Mek/Erk pathway via stabilization of c-Raf in cardiomyocytes.

The UPE (−125 to −37 bp) region of HSP90AA1 confers a 10-fold up-regulation of the core promoter. The core promoter (−36 to +37 bp) of HSP90AB1 confers constitutive expression, and the two typical HSE are responsible for maintaining a high level of constitutive expression.

Jan 28, 2020 · Here, we report a crucial role of HSP90A at the crossroads between NANOG-TCL1A axis and multi-aggressive properties of immune-edited tumor cells by identifying HSP90AA1 as a NANOG transcriptional...

As the stress-inducible isoform of the heat-shock protein 90 (HSP90), the HSP90AA1 gene encodes HSP90α and plays an important role in heat stress (HS) response. Therefore, this study aimed to investigate the role of the HSP90AA1 gene in cellular responses during HS and to identify functional SNPs as …

HSP90 proteins normally associate with other cochaperones and play important roles in folding newly synthesized proteins or stabilizing and refolding denatured proteins after stress. There are 2 major cytosolic HSP90 proteins, HSP90AA1, an inducible form, and HSP90AB1 (140572), a constitutive form.