HIF-1α/Wnt signaling-dependent control of gene transcription
Jul 9, 2019 · HIF-1α has been suggested to interplay with Wnt signaling components in order to activate a neuronal differentiation process in both normal brain and glioblastoma (GBM). …
HIF-1α/Wnt signaling-dependent control of gene transcription …
A HIF-1α/Wnt signaling-controlled gene signature involved in neuronal differentiation is progressively switched off in high-grade gliomas. By increasing analysis resolution, we …
HIF modulation of Wnt signaling regulates skeletal myogenesis ... - PubMed
Jul 15, 2015 · Analyses of Hif1a mutant muscle and Hif1a-depleted muscle progenitors further suggest that HIF1α represses myogenesis through inhibition of canonical Wnt signaling. Our …
Hypoxia-inducible factor-1α and Wnt/β-catenin signaling …
The present study aimed to examine the association between hypoxia-inducible factor (HIF)-1α and the Wnt/β-catenin signaling pathway in a hypoxic environment. The study also aimed to …
The Key Role of the WNT/β-Catenin Pathway in Metabolic …
The activation of the Wnt/β-catenin pathway induces gene transactivation via WNT target genes, c-Myc and cyclin D1, or via HIF-1α. This in turn encodes aerobic glycolysis enzymes, including …
Interaction between β-catenin and HIF-1 promotes cellular
Jan 14, 2007 · We show that hypoxia inhibits β-catenin–T-cell factor-4 (TCF-4) complex formation and transcriptional activity, resulting in a G1 arrest that involves the c-Myc–p21 axis. …
HIF-1α inhibits Wnt signaling pathway by activating Sost ... - PubMed
Jun 11, 2013 · As a master regulator of hypoxia, hypoxia-inducible factor-1α (HIF-1α) has been reported to couple angiogenesis to osteogenesis. Our recent study has demonstrated that …
HIF modulation of Wnt signaling regulates skeletal myogenesis
Jul 7, 2015 · Analyses of Hif1a mutant muscle and Hif1a-depleted muscle progenitors further suggest that HIF1α represses myogenesis through inhibition of canonical Wnt signaling. Our …
An oxygen-insensitive Hif-3α isoform inhibits Wnt signaling by ...
Genetic deletion of Hif-3α2 by CRISPR/Cas9 genome editing increases, while Hif-3α2 overexpression decreases, Wnt/β-catenin signaling. This action is independent of its HRE …
Oligodendrocyte-Encoded HIF Function Couples Postnatal Myelination and ...
Jul 17, 2014 · Here, we show that oxygen tension, mediated by OPC-encoded hypoxia-inducible factor (HIF) function, is an essential regulator of postnatal myelination. Constitutive HIF1/2α …