Homeobox protein Hox-A11 is a protein that in humans is encoded by the HOXA11 gene. [5][6][7] In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes.

Mar 30, 2025 · HOXA11 (Homeobox A11) is a Protein Coding gene. Diseases associated with HOXA11 include Radioulnar Synostosis With Amegakaryocytic Thrombocytopenia 1 and Radio-Ulnar Synostosis-Amegakaryocytic Thrombocytopenia Syndrome. Among its related pathways are Kidney development and Nervous system development.

Jul 18, 2019 · Here, using a newly generated Hoxa11-CreERT2 lineage-tracing system, we show Hoxa11-lineage marked cells give rise to all skeletal lineages throughout the life of the animal and persist as MSCs.

Jun 1, 2021 · Among the four genes (Hoxa11, PR domain zinc finger protein 5, Iroquois-class homeodomain protein IRX-5 and homeobox protein PKNOX2) mapped to the GO term ‘sequence-specific DNA’, HOXA11 upregulation was associated with AML harboring MLL-t and RAS signaling mutations based on a meta-analysis using data …

HOXA11 is critical for development and maintenance of uterosacral ligaments and deficient in pelvic prolapse. HOXA gene expression is up-regulated at the ectopic implantation site in the fallopian tube and it may play a role in ectopic pregnancies.

Title: lncRNA HOXA11-AS maintains the stemness of oral squamous cell carcinoma stem cells and reduces the radiosensitivity by targeting miR-518a-3p/PDK1. The lncRNA HOXA11-AS acts as a tumor promoter in breast cancer through regulation of the miR-125a-5p/TMPRSS4 axis.

Jul 27, 2018 · Recently, a novel identified homeobox (HOX) A11 antisense lncRNA, HOXA11-AS, 1,628 bp in length, has been excessively highlighted to be an essential initiator and facilitator in the process of malignant tumor proliferation and metastasis.

Aug 18, 2023 · HOXA11 transcriptionally regulates TGFβ1 expression and activates the TGFβ1/Smad2 pathway, which not only promotes EMT development but also induces VEGF-C secretion and lymphangiogenesis.

HOXA11 is a gene belonging to the HOX cluster that plays a role in hematologic malignancies, particularly in AML, MDS, CML, and CMML, as well as their paralogues in the B and C clusters. AI generated definition based on: Hematology (Seventh Edition) , 2018

Aug 30, 2019 · In contrast, Hoxa10 and Hoxa11 induced morphogenesis of endometrioid-like and mucinous-like tumors, respectively. Hoxa7 showed no lineage specificity, but promoted the abilities of Hoxa9, Hoxa10, and Hoxa11 to induce differentiation along their respective pathways.