HLA-DR3 is composed of the HLA-DR17 and HLA-DR18 split 'antigens' serotypes. DR3 is a component gene- allele of the AH8.1 haplotype in Northern and Western Europeans. Genes between B8 and DR3 on this haplotype are frequently associated with autoimmune disease.

HLA-DR is an MHC class II cell surface receptor encoded by the human leukocyte antigen complex on chromosome 6 region 6p21.31. The complex of HLA-DR (Human Leukocyte Antigen – DR isotype) and peptide, generally between 9 and 30 amino acids in length, constitutes a ligand for the T-cell receptor (TCR).HLA (human leukocyte antigens) were originally defined as cell …

Jul 18, 2013 · Studies examining HLA class II have consistently replicated the HLA-DR2 (DRB1*15:01), HLA-DR3 (DRB1*03:01), HLA-DRB1*08:01, and HLA-DQA1*01:02 alleles associated with the disease in American and European populations with a two fold RR conferred by each allele (25–28).

Idiopathic dilated cardiomyopathy (IDC) has been hypothesized as a multifactorial disorder initiated by an environment trigger in individuals with predisposing human leukocyte antigen (HLA) alleles. Published data on the association between HLA-DR3 ...

Feb 7, 2011 · HLA-DR3 is a genetic marker highly associated with a kidney disorder called Membranous Nephropathy (MN), particularly in European populations. AI generated definition based on: Seldin and Giebisch's The Kidney (Fourth Edition), 2008

Type I diabetes mellitus is associated with HLA-DR3,4 heterozygotes, and the absence of asparagine at position 57 on the DQβ1 chain appears to render susceptibility to this disease.

Apr 4, 2007 · In a recent study, we demonstrated that the disease-associated HLA-DR2 containing haplotype is localized to a 500 kb interval that includes the DR and DQ genes and two genes of unknown function...

The human HLA-DR3 haplotype consists of two functional genes (DRB1*03 and DRB3*01) and one pseudogene (DRB2), arranged in the order DRB1...DRB2...DRB3 on the chromosome. To shed light on the origin of the haplotype, we sequenced 1480 nucleotides of the HLA-DRB2 gene and long stretches of two other g …

May 17, 2013 · The Diabetes Autoimmunity Study of the Young (DAISY) group reported that siblings sharing both HLA-DR3/4 types identical by descent had a 55% risk of T1D by age 12 years and 63% risk of developing islet cell autoantibodies by age 7 years.

We describe the relation of HLA-DR3 and DR4 antigens to the 14-year incidence and progression of diabetic retinopathy and macular edema in this cohort. Design: A population-based cohort study. Participants: A probability sample of male and female patients receiving primary care for diabetes in 11 counties of southern Wisconsin