The presence of the gene HLA–B51 is a risk factor for this disease. However, it must be emphasized that presence of the gene in and of itself is not enough to cause Behcet’s: many people possess the gene, but relatively few develop Behcet’s.

HLA-B51 (B51) is an HLA-B serotype. The serotype identifies the more common HLA-B*51 gene products. [1] B51 is a split antigen of the broad antigen B5, and is a sister serotype of B52. [2] There are many alleles within the B*51 allele group. B51 is associated with several diseases, including Behçet's disease.

HLA-B∗51 remains the most important genetic factor in Behçet's syndrome, despite the recent identification of several susceptibility genes. The prevalence of HLA-B∗51 has been shown to differ among phenotype-based clinical clusters in the same patient population.

Apr 14, 2025 · HLA B*51 is the predominant risk factor for BD in all populations studied, however not all BD patients carry the B*51 allele. The disease is prevalent in countries in the eastern Mediterranean, the Middle East, and East Asia and in individuals of Middle Eastern, Far Eastern and Mediterranean decent.

To quantify by meta-analysis the genetic effect of the HLA–B5 or HLA–B51 (HLA–B51/B5) allele on the risk of developing Behçet’s disease (BD) and to look for potential effect modifiers. Relevant studies were identified using the PubMed Medline database and manual searches of …

Studies reveal that HLA-B*51 is the primary genetic risk factor, but non-HLA genes (ERAP1, IL-10, IL23R/IL-12RB2), as well as innate immunity genes (FUT2, MICA, TLRs), also contribute. Genome-wide studies emphasize the significance of ERAP1 and HLA-I epistasis.

Behcet’s disease is a systemic inflammatory vasculitis, characterised by oral ulcers, genital ulcers, skin lesions and ocular lesions. It can affect the blood vessels of almost any system involving the gastrointestinal and neurological systems. The association of HLA-B51 and Behcet's disease has been reported in patients of many ethnic groups.

May 3, 2024 · HLA-B*51 is strongly associated with BD with approximately 60% of patients being positive, as opposed to about 15% positivity in healthy individuals across different ethnicities. Due to low specificity, HLA-B*51 positivity is not diagnostic for BD.

Oct 15, 2009 · The strength of the association between BD and HLA-B51/B5, and its consistency across populations of various ethnicities, lends further support to this allele being a primary and causal risk determinant for BD.

Jan 1, 2022 · Recent findings: HLA-B∗51 remains the most important genetic factor in Behçet's syndrome, despite the recent identification of several susceptibility genes. The prevalence of HLA-B∗51 has been shown to differ among phenotype-based clinical clusters in …