Inhibition of glycolytic enzyme hexokinase II (HK2) suppresses …
Feb 16, 2016 · Our pharmacological studies confirmed that 2-DG, an inhibitor of HK2, inhibited human and mouse lung cancer cell growth through inducing cell apoptosis and autophagy. …
Hexokinase 2 Inhibition and Biological Effects of BNBZ and Its ...
Hexokinase 2 (HK2), an enzyme of the sugar kinase family, plays a dual role in glucose metabolism and mediating cancer cell apoptosis, making it an attractive target for cancer …
The development of small-molecule inhibitors targeting …
Sep 1, 2022 · Hexokinase 2 (HK2) is the rate-limiting enzyme catalyzing the first step of glycolysis, and is often overexpressed in most cancer cells. Thus, targeting HK2 appears to be …
Novel mutation in hexokinase 2 confers resistance to 2 …
We here describe a genetic screen in Saccharomyces cerevisiae that generated a novel spontaneous mutation in hexokinase-2, hxk2G238V, that confers resistance to the toxic …
Inhibiting glycolytic metabolism enhances CD8 - JCI
Sep 16, 2013 · Conversely, experiments using the glucose analog 2-deoxyglucose (2DG), an inhibitor of hexokinase-2 (Hk2), indicated that limiting glycolysis in CD8 + T cells favors the …
Hexokinases II‐mediated glycolysis governs susceptibility to crizotinib ...
Nov 2, 2021 · HK2 expression was effectively suppressed by 2DG alone, or in combination with crizotinib, rendering HK2 susceptible to 2DG treatment. In conclusion, HK2 may play a central …
Hexokinases II-mediated glycolysis governs susceptibility to
Conclusions: These results indicate that HK2-mediated glycolysis plays a crucial role in the increased tolerance of ALK + NSCLC cells to crizotinib. 2DG may sensitize ALK + NSCLC to …
Novel selective hexokinase 2 inhibitor Benitrobenrazide blocks …
Feb 1, 2021 · Here, we report a novel selective HK2 inhibitor Benitrobenrazide (BNBZ), with nanomolar inhibitory potency. In vitro, BNBZ directly binds to HK2, induces apoptosis, and …
Chemical inhibitors of hexokinase-2 enzyme reduce lactate
The goal of this study was to reduce lactate in CHO cell cultures by adding chemical inhibitors to hexokinase-2 (HK2), the enzyme catalyzing the conversion of glucose to glucose 6 …
Inhibition of glycolytic enzyme hexokinase II (HK2) suppresses …
Our pharmacological studies confirmed that 2-DG, an inhibitor of HK2, inhibited human and mouse lung cancer cell growth through inducing cell apoptosis and autophagy. HK2 is a …