Vpu protein - Wikipedia
Vpu is an accessory protein that in HIV is encoded by the vpu gene. Vpu stands for "Viral Protein U". The Vpu protein acts in the degradation of CD4 in the endoplasmic reticulum and in the …
Vpu Protein: The Viroporin Encoded by HIV-1 - PMC
Viral protein U (Vpu) is a lentiviral viroporin encoded by human immunodeficiency virus type 1 (HIV-1) and some simian immunodeficiency virus (SIV) strains. This small protein of 81 amino …
Role of Viral Protein U (Vpu) in HIV-1 Infection and Pathogenesis
Jul 27, 2021 · Vpu is an HIV-1 accessory protein generated from Env / Vpu encoded bicistronic mRNA and localized in cytosolic and membrane regions of cells capable of being infected by …
Modulation of HIV-1-host interaction: role of the Vpu accessory protein
Dec 22, 2010 · Viral protein U (Vpu) is a type 1 membrane-associated accessory protein that is unique to human immunodeficiency virus type 1 (HIV-1) and a subset of related simian …
Various plus unique: Viral protein U as a plurifunctional protein for ...
Feb 28, 2017 · Viral protein U (Vpu) is a unique protein encoded by human immunodeficiency virus type 1 (HIV-1) and related lentiviruses, playing multiple roles in viral replication and …
Insights into the oligomeric structure of the HIV-1 Vpu protein
We studied the structure and function of the viral protein U (Vpu) protein encoded by the human immunodeficiency virus 1 (HIV-1). Vpu is among the key HIV-1 proteins aiding virus adaptation …
Vpu modulates DNA repair to suppress innate sensing and hyper ... - Nature
Jul 20, 2020 · Here, we show that the late HIV-1 accessory protein Vpu hijacks DNA repair mechanisms to promote degradation of nuclear viral cDNA in cells that are already …
HIV-1 Vpu – An ion channel in search of a job - PMC
Vpu is a small membrane protein encoded by HIV-1 and some SIV isolates. The protein is best known for its ability to degrade CD4 and to enhance the release of progeny virions from …
Role of HIV-1 Vpu protein for virus spread and pathogenesis
Jul 1, 2008 · Vpu is an accessory viral protein almost unique to HIV-1 among primate immunodeficiency viruses, and has two major functions: degradation of the CD4 molecule in …
HIV-1 Vpu is a potent transcriptional suppressor of NF-κB-elicited ...
Many viral pathogens target innate sensing cascades and/or cellular transcription factors to suppress antiviral immune responses. Here, we show that the accessory viral protein U (Vpu) …
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