Oct 29, 2015 · Ablation of Grb2 interactions reduces PI3-K recruitment to TGF-RII and decreases PIP3 production and dampens JNK phosphorylation and AP-1-driven transcriptional activity down to levels...

Oct 29, 2015 · Ablation of Grb2 interactions reduces PI3-K recruitment to TGF-RII and decreases PIP3 production, and dampens JNK phosphorylation and AP-1-driven transcriptional activity down to levels characteristic of attenuated macrophages.

Recruitment of Grb2 to TβR-II in normal MECs converts TGF-β from a cytostatic to oncogenic cytokine, and as such, enables TGF-β to stimulate p38 MAPK, and to induce EMT and invasion in normal MECs.

Oct 29, 2015 · Pathway showing how TGF-β2 induction of Grb2 recruits PI3-K to TGF-RII to activate AP-1-driven gene transcription that underpins heightened adhesion and invasiveness of Theileria-transformed virulent macrophages.

Transforming growth factor β (TGF-β) family members signal via heterotetrameric complexes of type I and type II dual specificity kinase receptors.

Dec 30, 2008 · Grb2 is an adaptor protein that is bound to Sos in the cytoplasm in the absence of ligand stimulation. Upon RTK activation, Grb2/Sos complex is recruited to the RTK, which brings Sos to the...

Sep 28, 2024 · LncRNA TBUR1 is activated by TGF-β via Smad3/4 in LUAD. TBUR1 triggers EMT, enhances LUAD cell invasion and metastasis. TBUR1 interacts with hnRNPC to regulate GRB2 expression in an m 6 A-dependent manner. TBUR1 is upregulated in LUAD tissues and associated with poor prognosis.

Ablation of Grb2 interactions reduces PI3-K recruitment to TGF-RII and decreases PIP3 production, and dampens JNK phosphorylation and AP-1-driven transcriptional activity down to levels...

Aug 2, 2007 · TGF‐β‐induced ShcA phosphorylation induces ShcA association with Grb2 and Sos, thereby initiating the well‐characterised pathway linking receptor tyrosine kinases with Erk MAP kinases. We also found that TβRI is tyrosine phosphorylated in response to TGF‐β.

We demonstrated previously that growth factor receptor-bound protein 2 (Grb2) associates with the transforming growth factor-beta (TGF-beta) type II receptor [TbetaR-II] upon its phosphorylation on Tyr284 by Src.