Network dysfunction in association with altered brain levels of glutamate (Glu) and gamma-aminobutyric acid (GABA) have been identified in both animal and human studies of depression.

Oct 3, 2022 · Here we identify a novel glutamate-GABA A R interaction mediated by a direct glutamate binding of the GABA A R. In HEK293 cells overexpressing recombinant GABA A Rs, glutamate and its analog...

The transcellular recycling of glutamate, GABA, and glutamine is known as the glutamate‐glutamine cycle (right, pink trace) and the GABA‐glutamine cycle (left, blue trace), collectively also called the glutamate/GABA‐glutamine cycle.

The rat dyskinetic syndrome has Glu/GABA-Gln abnormalities. "Tiapride" upregulated the protein expression of GS and EAAT₂, reduce Glu levels, increase γ-GABA levels, and eventually improve amino acid neurotransmitter imbalance.

A metabolite shuttle known as the glutamate/GABA-glutamine cycle describes the release of neurotransmitter glutamate or GABA from neurons and subsequent uptake into astrocytes. In return, astrocytes release glutamine to be taken up into …

γ-aminobutyric acid (GABA) and glutamate (Glu), the main inhibitory and excitatory neurotransmitters in the brain, respectively, are critical for normal neurological function.

Aug 18, 2022 · Using a within-subject design, we hypothesized that reduction in depressive symptoms correlates with reduction in Glx/GABA in the anterior cingulate cortex (ACC). The present trial is a...

Oct 9, 2023 · Elucidating the potential links between the GLU/GABA to GLN metabolic cycle disruptions and the onset of depressive and insomnia disorders following a stroke.

Sep 28, 2021 · Increased glutamatergic metabolite levels and reduced GABA levels indicate that the disruption of excitatory/inhibitory balance may be related to the pathophysiology of schizophrenia-spectrum...

Glutamine (Gln), glutamate (Glu) and gamma-amino butyric acid (GABA) are essential amino acids for brain metabolism and function. Astrocytic-derived glutamine is the precursor of the two most important neurotransmitters: glutamate, an excitatory neurotransmitter, and GABA, an inhibitory neurotransmi …