Lipid elements and metabolism regulate gene expression, DNA duplication and transcription directly by lipid binding to nuclear transcriptional proteins and receptors, and/or indirectly by modulating the intra‐nuclear microenvironment, membrane biophysics or …

In this review, we discuss the latest advances in discovery of genetic loci associated with plasma lipids, the functional validation of some of these loci that has been performed to date, and recent advances in our understanding of the role of long noncoding …

Dec 10, 2024 · We created a dataset of >9,000 lipid nanoparticle activity measurements and used it to train a directed message-passing neural network for prediction of nucleic acid delivery with diverse lipid...

Mar 17, 2025 · For source 2, a gene list linked to lipids was downloaded from the GWAS Catalog (EFO_0004529) and the cutoff was p-value ≤ 1E − 30. Then we removed duplicate genes, miRNA, or lncRNA genes from the list to obtain the candidates of the current study. For source 3, twenty literatures were collected to comprehensively search the genes related ...

Sep 21, 2020 · To discover the genetics of lipid features obtained through high-resolution liquid chromatography–tandem mass spectrometry, we analysed liver and plasma from 384 diversity outbred mice, and...

Cationic lipids have become known as one of the most versatile tools for the delivery of DNA, RNA and many other therapeutic molecules, and are especially attractive because they can be easily designed, synthesized and characterized.

Apr 30, 2021 · Lipids and carbohydrates regulate gene expression by means of molecules that sense these macronutrients and act as transcription factors.

Mar 3, 2025 · DNA delivery using lipid nanoparticles results in severe toxicity in mice. However, we find that the incorporation of endogenous anti-inflammatory lipids into the lipid nanoparticles...

Jan 29, 2025 · Lipid nanoparticles (LNPs) are an effective delivery system for gene therapeutics. By optimizing their formulation, the physiochemical properties of LNPs can be tailored to improve tissue penetration, cellular uptake, and precise targeting.

Mar 20, 2025 · The FADS1 gene encodes Δ5 desaturase, which is crucial for converting ALA to EPA, while the ELOVL2 gene encodes an elongase enzyme (i.e., ELOVL fatty acid elongase 2) involved in converting EPA to DHA. Genetic polymorphisms in these genes can lead to variations in enzyme activity, affecting the percentages of EPA, DHA, and other related fatty ...