Transport of vesicles within the cell, and vesicle-mediated secretion and uptake, through GTPase control of vesicle coat assembly. GTPases are active when bound to GTP and inactive when bound to GDP.

Keywords: Translation, Ribosome, GTPase, Rbg1, Rbg2, Tma46, Gir2. Introduction. The developmentally regulated GTP-binding (DRG) proteins are a family of highly conserved GTPases that consists of two closely related paralogs: DRG1 and DRG2 (Fig. 1) .

Jan 1, 2019 · Small GTPase is a kind of GTP-binding protein commonly found in eukaryotic cells. It plays an important role in cytoskeletal reorganization, cell polarity, cell cycle progression, gene expression and many other significant events in cells, such as …

They are a type of G-protein found in the cytosol that are homologous to the alpha subunit of heterotrimeric G-proteins, but unlike the alpha subunit of G proteins, a small GTPase can function independently as a hydrolase enzyme to bind to and hydrolyze a guanosine triphosphate (GTP) to form guanosine diphosphate (GDP).

Dec 15, 2022 · The study of GTPases has sparked widespread enthusiasm for over 20 years. Tool compounds and lead drugs that pharmacologically inhibit GTPase pathways have shown promise. Recently, FDA granted accelerated approval to adagrasib for KRAS G12C-mutated non-small cell lung cancer. The articles within our SI add significant value to the development ...

At least two alternative mechanisms for activation of the oncogenic potential of GTPases have been found. Point mutations that reduce their GAP-stimulated GTPase activity would render proteins with a much lower efficiency to catalyse GTP hydrolysis.

A GTPase is an enzyme that facilitates the conversion of guanosine triphosphate (GTP) to guanosine diphosphate (GDP). It plays a crucial role in regulating various cellular processes such as cell growth, differentiation, migration, and vesicle trafficking.

Jan 1, 2001 · GTPase-activating proteins (GAP) and GDP/GTP exchange factors (GEF) control the level of the active form. Despite the tremendous progress, regulation of the various GTPases and their pathways remains one of the most intricate and challenging aspects of cellular biology and biochemistry.

Small GTPase is a kind of GTP-binding protein commonly found in eukaryotic cells. It plays an important role in cytoskeletal reorganization, cell polarity, cell cycle progression, gene expression and many other significant events in cells, such as the interaction with foreign particles.

The study of GTPases has sparked widespread enthusiasm for over 20 years. Tool compounds and lead drugs that pharmacologically inhibit GTPase pathways have shown promise. Recently, FDA granted accelerated approval to adagrasib for KRAS G12C-mutated non-small cell lung cancer. The articles within our SI add significant value to the development ...