Jul 1, 2024 · High throughput screening identified GSTP1 as a critical gene for PIP action. Functional validation of HCC cells by constructing cell lines with knockout or overexpression of GSTP1 genes highlights the potential of GSTP1 as a …

Nov 27, 2023 · Glutathione (GSH) peroxidase 4 (GPX4) and GSH-independent ferroptosis suppressor protein 1 (FSP1) have been identified as major defenses. Here, we uncover a protective mechanism mediated by GSH S -transferase P1 (GSTP1) by monitoring proteinomic dynamics during ferroptosis.

We have created a novel glutathione S-transferase π1 (gstp1) knockout (KO) zebrafish model and used it for comparative analyses of redox homeostasis and response to drugs that cause endoplasmic reticulum (ER) stress and induce the unfolded protein response (UPR).

We have created a novel glutathione S-transferase π1 (gstp1) knockout (KO) zebrafish model and used it for comparative analyses of redox homeostasis and response to drugs that cause endoplasmic reticulum (ER) stress and induce the unfolded protein response (UPR).

Kindlin-2 regulates GSTP1 expression by affecting its polyubiquitination. A, immunoblotting analysis of GSTP1 protein levels in primary hepatocyte isolated from Kindlin-2 KO and control mice.

Jan 15, 2015 · Our data demonstrate that GSTP1/P2 contribute to the finely tuned activation levels of proliferation signaling pathways and to the downstream expression of cell cycle regulators in order to...

May 1, 2023 · In our research, GSTP1 was revealed to upregulate the S-glutathionylation level of Pik3r1 through Cys498 and Cys670, thereby decreasing its phosphorylation, further controlling the alteration of autophagic flux via the Pik3r1-AKT-mTOR axis, and lastly altering osteoclast formation in vitro.

Apr 25, 2019 · FBX8 directly targets GSTP1 for ubiquitin-mediated proteasome degradation in CRC. GSTP1 promotes the proliferation, invasion, and metastasis of CRC cells. Furthermore, GSTP1 is upregulated in...

敲除Gstp1基因exon 3-5，建立Gstp1基因敲除小鼠模型。 *使用本品系发表的文献需注明: Gstp1-KO mice (Cat. NO. 待定) were purchased from Shanghai Model Organisms Center, Inc.. 相关品系

We have created a novel glutathione S-transferase π1 (gstp1) knockout (KO) zebrafish model and used it for comparative analyses of redox homeostasis and response to drugs that cause endoplasmic reticulum (ER) stress and induce the unfolded protein response (UPR).