In this review, we discuss the role of first line effectors that act directly on the GHR at the cell surface including ADAM17, JAK2, SRC family member Lyn, Ubc13/CHIP, proteasome, βTrCP, …

Feb 8, 2019 · Human growth hormone (GH) is a peptide hormone that is secreted from the anterior pituitary. It has a central function of regulating postnatal growth and metabolism and …

Growth hormone activates the Janus kinase (JAK)–signal transducer and activator of transcription (STAT) signaling pathway, and recent studies have provided a new understanding of the …

Growth hormone receptor (GHR) is a transmembrane protein consisting of 620 amino acids. The receptor is part of the Type I cytokine receptor family of receptors. GHR exists in two forms as …

Apr 15, 2021 · Given the great heterogeneity of cell types located in the PVH, we performed a detailed analysis of the neurochemical identity of GH-responsive cells to understand the …

Aug 22, 2023 · In this context, anti-Müllerian hormone (AMH), growth hormone (GH), and insulin-like growth factor 1 (IGF1) were shown to improve GnRH neuron migration and function in …

Jan 15, 2021 · Growth hormone (GH) actions via initiating cell signalling through the GH receptor (GHR) are important for many physiological processes, in addition to its well-known role in …

Oct 15, 2020 · Growth hormone-releasing hormone (GHRH) regulates the secretion of growth hormone that virtually controls metabolism and growth of every tissue through its binding to …

Mar 16, 2018 · In this Review, we describe the history of GH research and clinical use with a particular focus on disorders in childhood. The great complexity of the growth hormone …

Feb 1, 2018 · GHR signaling in humans with mutated GHR and absent GH counter-regulation is associated to less DNA damage and mutagenic events, efficient apoptosis, enhanced insulin …